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Title: Evidence for type-specific DNA methylation patterns in epilepsy: a discordant monozygotic twin approach.
Austin Authors: Mohandas, Namitha;Loke, Yuk Jing;Hopkins, Stephanie;Mackenzie, Lisa;Bennett, Carmen;Berkovic, Samuel F ;Vadlamudi, Lata;Craig, Jeffrey M
Affiliation: Epilepsy Research Centre, Department of Medicine, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australia
School of Medicine & Public Health, University of Newcastle, Newcastle, New South Wales, Australia
Centre for Molecular & Medical Research, School of Medicine, Deakin University, Geelong, Victoria 3220, Australia
Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Queensland, Australia
Royal Brisbane & Women's Hospital, Queensland, Australia
Environmental & Genetic Epidemiology Research, Murdoch Children's Research Institute, Royal Children's Hospital, Flemington Road, Parkville, Victoria, Australia
Department of Paediatrics, University of Melbourne, Flemington Road, Parkville, Victoria, Australia
Issue Date: Jun-2019 2019-06-05
Publication information: Epigenomics 2019; 11(8): 951-968
Abstract: Aim: Epilepsy is a common neurological disorder characterized by recurrent seizures. We performed epigenetic analyses between and within 15¬†monozygotic (MZ) twin pairs discordant for focal or generalized epilepsy. Methods: DNA methylation analysis was performed using Illumina Infinium MethylationEPIC arrays, in blood and buccal samples. Results: Differentially methylated regions between epilepsy types associated with PM20D1 and GFPT2 genes in both tissues. Within MZ discordant twin pairs, differentially methylated regions associated with OTX1 and ARID5B genes for generalized epilepsy and TTC39C and DLX5 genes for focal epilepsy. Conclusion: This is the first epigenome-wide association study, utilizing the discordant MZ co-twin model, to deepen our understanding of the neurobiology of epilepsy.
DOI: 10.2217/epi-2018-0136
ORCID: 0000-0003-4580-841X
PubMed URL: 31166810
Type: Journal Article
Subjects: DNA methylation
discordant monozygotic twins
Appears in Collections:Journal articles

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