Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/20956
Title: A Human Sensory Pathway Connecting the Foot to Ipsilateral Face That Partially Bypasses the Spinal Cord.
Austin Authors: Silberstein, Morry;Nunn, Andrew K ;Drummond, Peter D;Wan, Dawn Wong Lit;Alexander, Janette;Millard, Melinda;Galea, Mary P 
Affiliation: School of Psychology, Murdoch University, Murdoch, WA, Australia
Department of Medicine, University of Melbourne, Melbourne, Victoria, Australia
School of Health and Biomedical Sciences, RMIT University, Melbourne, Victoria, Australia
School of Molecular and Life Sciences, Curtin University, Perth, WA, Australia
Victorian Spinal Cord Service, Austin Health, Heidelberg, Victoria, Australia
Issue Date: 22-May-2019
metadata.dc.date: 2019
Publication information: Frontiers in neuroscience 2019; 13: 519
Abstract: Human sensory transmission from limbs to brain crosses and ascends through the spinal cord. Yet, descriptions exist of ipsilateral sensory transmission as well as transmission after spinal cord transection. To elucidate a novel ipsilateral cutaneous pathway, we measured facial perfusion following painfully-cold water foot immersion in 10 complete spinal cord-injured patients, 10 healthy humans before and after lower thigh capsaicin C-fiber cutaneous conduction blockade, and 10 warm-immersed healthy participants. As in healthy volunteers, ipsilateral facial perfusion in spinal cord injured patients increased significantly. Capsaicin resulted in contralateral increase in perfusion, but only following cold immersion and not in 2 spinal cord-injured patients who underwent capsaicin administration. Supported by skin biopsy results from a healthy participant, we speculate that the pathway involves peripheral C-fiber cross-talk, partially bypassing the cord. This might also explain referred itch and jogger's migraine and it is possible that it may be amenable to training spinal-injured patients to recognize lower limb sensory stimuli.
URI: http://ahro.austin.org.au/austinjspui/handle/1/20956
DOI: 10.3389/fnins.2019.00519
PubMed URL: 31191224
ISSN: 1662-4548
Type: Journal Article
Subjects: C-fiber
afferent
capsaicin
neuroanantomy
pain
Appears in Collections:Journal articles

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