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https://ahro.austin.org.au/austinjspui/handle/1/20814| Title: | Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes. | Austin Authors: | Malik, Rainer;Chauhan, Ganesh;Traylor, Matthew;Sargurupremraj, Muralidharan;Okada, Yukinori;Mishra, Aniket;Rutten-Jacobs, Loes;Giese, Anne-Katrin;van der Laan, Sander W;Gretarsdottir, Solveig;Anderson, Christopher D;Anderson, Christopher D;Chong, Michael;Adams, Hieab H H;Ago, Tetsuro;Almgren, Peter;Amouyel, Philippe;Ay, Hakan;Bartz, Traci M;Benavente, Oscar R;Bevan, Steve;Salomaa, Veikko;Bevan, Steve;Boncoraglio, Giorgio B;Brown, Robert D;Butterworth, Adam S;Carrera, Caty;Carty, Cara L;Chasman, Daniel I;Chen, Wei-Min;Cole, John W;Correa, Adolfo;Sapkota, Bishwa R;Boncoraglio, Giorgio B;Cotlarciuc, Ioana;Cruchaga, Carlos;Danesh, John;de Bakker, Paul I W;DeStefano, Anita L;Hoed, Marcel den;Duan, Qing;Engelter, Stefan T;Falcone, Guido J;Schmidt, Reinhold;Gottesman, Rebecca F;Brown, Robert D;Grewal, Raji P;Gudnason, Vilmundur;Gustafsson, Stefan;Haessler, Jeffrey;Harris, Tamara B;Hassan, Ahamad;Havulinna, Aki S;Heckbert, Susan R;Schmidt, Carsten O;Holliday, Elizabeth G;Howard, George;Butterworth, Adam S;Hsu, Fang-Chi;Hyacinth, Hyacinth I;Ikram, M Arfan;Ingelsson, Erik;Irvin, Marguerite R;Jian, Xueqiu;Jiménez-Conde, Jordi;Schminke, Ulf;Johnson, Julie A;Jukema, J Wouter;Kanai, Masahiro;Carrera, Caty;Keene, Keith L;Kissela, Brett M;Kleindorfer, Dawn O;Kooperberg, Charles;Kubo, Michiaki;Lange, Leslie A;Sharma, Pankaj;Langefeld, Carl D;Langenberg, Claudia;Launer, Lenore J;Lee, Jin-Moo;Carty, Cara L;Lemmens, Robin;Leys, Didier;Lewis, Cathryn M;Lin, Wei-Yu;Lindgren, Arne G;Slowik, Agnieszka;Lorentzen, Erik;Magnusson, Patrik K;Maguire, Jane;Manichaikul, Ani;McArdle, Patrick F;Chasman, Daniel I;Meschia, James F;Mitchell, Braxton D;Mosley, Thomas H;Nalls, Michael A;Sudlow, Cathie L M;Ninomiya, Toshiharu;O'Donnell, Martin J;Psaty, Bruce M;Pulit, Sara L;Rannikmäe, Kristiina;Reiner, Alexander P;Chen, Wei-Min;Rexrode, Kathryn M;Rice, Kenneth;Rich, Stephen S;Tanislav, Christian;Ridker, Paul M;Rost, Natalia S;Rothwell, Peter M;Rotter, Jerome I;Rundek, Tatjana;Sacco, Ralph L;Sakaue, Saori;Cole, John W;Sale, Michele M;Salomaa, Veikko;Tatlisumak, Turgut;Sapkota, Bishwa R;Schmidt, Reinhold;Schmidt, Carsten O;Schminke, Ulf;Sharma, Pankaj;Slowik, Agnieszka;Sudlow, Cathie L M;Tanislav, Christian;Correa, Adolfo;Tatlisumak, Turgut;Chong, Michael;Taylor, Kent D;Thijs, Vincent N S;Thorleifsson, Gudmar;Thorsteinsdottir, Unnur;Tiedt, Steffen;Trompet, Stella;Tzourio, Christophe;van Duijn, Cornelia M;Walters, Matthew;Cotlarciuc, Ioana;Taylor, Kent D;Wareham, Nicholas J;Wassertheil-Smoller, Sylvia;Wilson, James G;Wiggins, Kerri L;Yang, Qiong;Yusuf, Salim;Amin, Najaf;Aparicio, Hugo S;Arnett, Donna K;Attia, John;Thijs, Vincent N S;Cruchaga, Carlos;Beiser, Alexa S;Berr, Claudine;Buring, Julie E;Bustamante, Mariana;Caso, Valeria;Cheng, Yu-Ching;Choi, Seung Hoan;Chowhan, Ayesha;Cullell, Natalia;Thorleifsson, Gudmar;Dartigues, Jean-François;Danesh, John;Delavaran, Hossein;Delgado, Pilar;Dörr, Marcus;Engström, Gunnar;Ford, Ian;Gurpreet, Wander S;Hamsten, Anders;Heitsch, Laura;Thorsteinsdottir, Unnur;Hozawa, Atsushi;Ibanez, Laura;de Bakker, Paul I W;Ilinca, Andreea;Ingelsson, Martin;Iwasaki, Motoki;Jackson, Rebecca D;Jood, Katarina;Jousilahti, Pekka;Kaffashian, Sara;Tiedt, Steffen;Kalra, Lalit;Kamouchi, Masahiro;Kitazono, Takanari;DeStefano, Anita L;Kjartansson, Olafur;Kloss, Manja;Koudstaal, Peter J;Krupinski, Jerzy;Labovitz, Daniel L;Laurie, Cathy C;Trompet, Stella;Levi, Christopher R;Li, Linxin;Lind, Lars;Lindgren, Cecilia M;den Hoed, Marcel;Lioutas, Vasileios;Liu, Yong Mei;Lopez, Oscar L;Makoto, Hirata;Martinez-Majander, Nicolas;Tzourio, Christophe;Matsuda, Koichi;Minegishi, Naoko;Montaner, Joan;Morris, Andrew P;Muiño, Elena;Duan, Qing;Müller-Nurasyid, Martina;Norrving, Bo;Ogishima, Soichi;Parati, Eugenio A;van Duijn, Cornelia M;Peddareddygari, Leema Reddy;Pedersen, Nancy L;Pera, Joanna;Perola, Markus;Pezzini, Alessandro;Pileggi, Silvana;Engelter, Stefan T;Rabionet, Raquel;Riba-Llena, Iolanda;Ribasés, Marta;Walters, Matthew;Romero, Jose R;Roquer, Jaume;Rudd, Anthony G;Sarin, Antti-Pekka;Sarju, Ralhan;Sarnowski, Chloe;Sasaki, Makoto;Falcone, Guido J;Satizabal, Claudia L;Satoh, Mamoru;Wareham, Nicholas J;Sattar, Naveed;Sawada, Norie;Sibolt, Gerli;Sigurdsson, Ásgeir;Smith, Albert;Sobue, Kenji;Soriano-Tárraga, Carolina;Stanne, Tara;Gottesman, Rebecca F;Stine, O Colin;Adams, Hieab H H;Stott, David J;Strauch, Konstantin;Takai, Takako;Tanaka, Hideo;Tanno, Kozo;Teumer, Alexander;Tomppo, Liisa;Torres-Aguila, Nuria P;Touze, Emmanuel;Grewal, Raji P;Wassertheil-Smoller, Sylvia;Tsugane, Shoichiro;Uitterlinden, Andre G;Valdimarsson, Einar M;van der Lee, Sven J;Völzke, Henry;Wakai, Kenji;Weir, David;Williams, Stephen R;Wolfe, Charles D A;Wong, Quenna;Wilson, James G;Gudnason, Vilmundur;Xu, Huichun;Yamaji, Taiki;Sanghera, Dharambir K;Melander, Olle;Jern, Christina;Strbian, Daniel;Fernandez-Cadenas, Israel;Longstreth, W T;Rolfs, Arndt;Wiggins, Kerri L;Hata, Jun;Gustafsson, Stefan;Woo, Daniel;Rosand, Jonathan;Pare, Guillaume;Hopewell, Jemma C;Saleheen, Danish;Stefansson, Kari;Worrall, Bradford B;Kittner, Steven J;Yang, Qiong;Seshadri, Sudha;Fornage, Myriam;Haessler, Jeffrey;Markus, Hugh S;Howson, Joanna M M;Kamatani, Yoichiro;Debette, Stephanie;Dichgans, Martin;Harris, Tamara B;Hassan, Ahamad;Yusuf, Salim;Havulinna, Aki S;Heckbert, Susan R;Holliday, Elizabeth G;Howard, George;Hsu, Fang-Chi;Hyacinth, Hyacinth I;Ikram, M Arfan;Ingelsson, Erik;Irvin, Marguerite R;Jian, Xueqiu;Bis, Joshua C;Jiménez-Conde, Jordi;Johnson, Julie A;Jukema, J Wouter;Kanai, Masahiro;Keene, Keith L;Kissela, Brett M;Kleindorfer, Dawn O;Kooperberg, Charles;Kubo, Michiaki;Lange, Leslie A;Pastinen, Tomi;Langefeld, Carl D;Langenberg, Claudia;Launer, Lenore J;Lee, Jin-Moo;Lemmens, Robin;Leys, Didier;Lewis, Cathryn M;Lin, Wei-Yu;Lindgren, Arne G;Lorentzen, Erik;Ruusalepp, Arno;Magnusson, Patrik K;Maguire, Jane;Manichaikul, Ani;McArdle, Patrick F;Meschia, James F;Mitchell, Braxton D;Mosley, Thomas H;Nalls, Michael A;Ninomiya, Toshiharu;O'Donnell, Martin J;Schadt, Eric E;Psaty, Bruce M;Pulit, Sara L;Rannikmäe, Kristiina;Reiner, Alexander P;Rexrode, Kathryn M;Rice, Kenneth;Rich, Stephen S;Ridker, Paul M;Rost, Natalia S;Rothwell, Peter M;Koplev, Simon;Rotter, Jerome I;Rundek, Tatjana;Sacco, Ralph L;Sakaue, Saori;Sale, Michele M;Ago, Tetsuro;Björkegren, Johan L M;Codoni, Veronica;Civelek, Mete;Smith, Nicholas L;Trégouët, David A;Christophersen, Ingrid E;Roselli, Carolina;Lubitz, Steven A;Ellinor, Patrick T;Tai, E Shyong;Almgren, Peter;Kooner, Jaspal S;Kato, Norihiro;He, Jiang;van der Harst, Pim;Elliott, Paul;Chambers, John C;Takeuchi, Fumihiko;Johnson, Andrew D;Sanghera, Dharambir K;Melander, Olle;Amouyel, Philippe;Jern, Christina;Strbian, Daniel;Fernandez-Cadenas, Israel;Longstreth, W T;Rolfs, Arndt;Hata, Jun;Woo, Daniel;Rosand, Jonathan;Pare, Guillaume;Hopewell, Jemma C;Ay, Hakan;Saleheen, Danish;Stefansson, Kari;Worrall, Bradford B;Kittner, Steven J;Seshadri, Sudha;Fornage, Myriam;Markus, Hugh S;Howson, Joanna M M;Kamatani, Yoichiro;Debette, Stephanie;Bartz, Traci M;Dichgans, Martin;Malik, Rainer;Chauhan, Ganesh;Traylor, Matthew;Sargurupremraj, Muralidharan;Okada, Yukinori;Mishra, Aniket;Rutten-Jacobs, Loes;Giese, Anne-Katrin;van der Laan, Sander W;Benavente, Oscar R;Gretarsdottir, Solveig | Affiliation: | Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany Division of Cardiovascular Medicine, College of Medicine, University of Florida, Gainesville, FL, USA Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics, University of Florida, College of Pharmacy, Gainesville, FL, USA Department of Neurology, Yale University School of Medicine, New Haven, CT, USA Harvard Medical School, Boston, MA, USA Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA Center for Translational Science, George Washington University, Washington, DC, USA Children's Research Institute, Children's National Medical Center, Washington, DC, USA AA Martinos Center for Biomedical Imaging, Department of Radiology, MGH, Harvard Medical School, Boston, MA, USA Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA J. Philip Kistler Stroke Research Center, Department of Neurology, MGH, Boston, MA, USA Boston University School of Medicine, Boston, MA, USA Division of Genomic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA, USA Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA, USA Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA Department of Health Services, University of Washington, Seattle, WA, USA Center for Health Disparities, East Carolina University, Greenville, NC, USA British Heart Foundation, Cambridge Centre of Excellence, Department of Medicine, University of Cambridge, Cambridge, UK Department of Biology, East Carolina University, Greenville, NC, USA Laboratory of Epidemiology and Population Science, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany Program in Bioinformatics and Integrative Genomics, Harvard Medical School, Boston, MA, USA INSERM U1219 Bordeaux Population Health Research Center, University of Bordeaux, France Laboratory of Experimental Cardiology, Department of Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, University of Utrecht, Utrecht, the Netherlands deCODE genetics/AMGEN Inc., Reykjavik, Iceland Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan Department of Clinical Sciences, Lund University, Malmö, Sweden School of Life Science, University of Lincoln, Lincoln, UK Department of Cerebrovascular Diseases, Fondazione IRCCS Istituto Neurologico 'Carlo Besta', Milan, Italy Institute of Cardiovascular Research, Royal Holloway University of London, London, UK, and Ashford and St Peters Hospital, Surrey, UK School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK Department of Immunology, Genetics and Pathology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden Department of Neurology, Leeds General Infirmary, Leeds Teaching Hospitals NHS Trust, Leeds, UK Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands Neurovascular Research Group (NEUVAS), Neurology Department, Institut Hospital del Mar d'Investigació Mèdica, Universitat Autònoma de Barcelona, Barcelona, Spain Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands RIKEN Center for Integrative Medical Sciences, Yokohama, Japan MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge, UK INSERM U 1171, CHU Lille, Université Lille, Lille, France Bioinformatics Core Facility, University of Gothenburg, Gothenburg, Sweden Department of Biostatistics, University of Liverpool, Liverpool, UK Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK National Institute for Health and Welfare, Helsinki, Finland Institute for Community Medicine, SHIP-KEF, University Medicine Greifswald, Greifswald, Germany Department of Neurology, University Medicine Greifswald, Greifswald, Germany Institute of Cardiovascular Research, Royal Holloway University of London, London, UK, and Ashford and St Peters Hospital, Surrey, UK Department of Neurology, Jagiellonian University, Krakow, Poland Department of Neurology, Justus Liebig University, Giessen, Germany Karolinska Institutet, Stockholm, Sweden deCODE genetics/AMGEN Inc., Reykjavik, Iceland Aflac Cancer and Blood Disorder Center, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA deCODE genetics/AMGEN Inc., Reykjavik, Iceland Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany Department of Internal Medicine, Section Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands School of Medicine, Dentistry and Nursing at the University of Glasgow, Glasgow, UK MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge, UK Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore National Heart and Lung Institute, Imperial College London, London, UK Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands MRC-PHE Centre for Environment and Health, School of Public Health, Department of Epidemiology and Biostatistics and the NIHR Imperial Biomedical Research Centre, Imperial College London, London, UK Department of Medical Genetics, University Medical Center Utrecht, Utrecht, the Netherlands Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan Department of Clinical Sciences, Lund University, Malmö, Sweden Department of Pathology and Genetics, Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden Albrecht Kossel Institute, University Clinic of Rostock, Rostock, Germany Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK INSERM U1219 Bordeaux Population Health Research Center, University of Bordeaux, France DZHK, Greifswald, Germany MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany INSERM U1219 Bordeaux Population Health Research Center, University of Bordeaux, France Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA INSERM U1219 Bordeaux Population Health Research Center, University of Bordeaux, France Laboratory of Experimental Cardiology, Department of Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, University of Utrecht, Utrecht, the Netherlands deCODE genetics/AMGEN Inc., Reykjavik, Iceland Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan Department of Clinical Sciences, Lund University, Malmö, Sweden School of Life Science, University of Lincoln, Lincoln, UK Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany Department of Cerebrovascular Diseases, Fondazione IRCCS Istituto Neurologico 'Carlo Besta', Milan, Italy Institute of Cardiovascular Research, Royal Holloway University of London, London, UK, and Ashford and St Peters Hospital, Surrey, UK Department of Immunology, Genetics and Pathology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA Department of Neurology, Leeds General Infirmary, Leeds Teaching Hospitals NHS Trust, Leeds, UK Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands Neurovascular Research Group (NEUVAS), Neurology Department, Institut Hospital del Mar d'Investigació Mèdica, Universitat Autònoma de Barcelona, Barcelona, Spain Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands RIKEN Center for Integrative Medical Sciences, Yokohama, Japan Department of Neurology, Memory Clinic, Bordeaux University Hospital, Bordeaux, France MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge, UK INSERM U 1171, CHU Lille, Université Lille, Lille, France Bioinformatics Core Facility, University of Gothenburg, Gothenburg, Sweden Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan Department of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK National Institute for Health and Welfare, Helsinki, Finland Institute for Community Medicine, SHIP-KEF, University Medicine Greifswald, Greifswald, Germany Department of Neurology, University Medicine Greifswald, Greifswald, Germany Bordeaux Population Health Research Center, INSERM, UMR 1219, Université Bordeaux, Bordeaux, France Institute of Cardiovascular Research, Royal Holloway University of London, London, UK, and Ashford and St Peters Hospital, Surrey, UK Department of Neurology, Jagiellonian University, Krakow, Poland Department of Neurology, Justus Liebig University, Giessen, Germany deCODE genetics/AMGEN Inc., Reykjavik, Iceland Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany Center for Public Health Genomics and Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA Department of Internal Medicine, Section Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands School of Medicine, Dentistry and Nursing at the University of Glasgow, Glasgow, UK MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge, UK Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands German Center for Neurodegenerative Diseases (DZNE), Munich, Germany INSERM, U1061, Université Montpellier, Montpellier, France Centre for Research in Environmental Epidemiology, Barcelona, Spain Department of Neurology, Università degli Studi di Perugia, Umbria, Italy Stroke Pharmacogenomics and Genetics, Fundacio Docència i Recerca MutuaTerrassa, Terrassa, Spain Neurovascular Research Laboratory. Vall d'Hebron Institut of Research, Neurology and Medicine Departments-Universitat Autònoma de Barcelona. Vall d'Hebrón Hospital, Barcelona, Spain Department of Clinical Sciences, Lund University, Malmö, Sweden Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA Robertson Center for Biostatistics, University of Glasgow, Glasgow, UK Tohoku Medical Megabank Organization, Sendai, Japan Department of Public Health and Caring Sciences/Geriatrics, Uppsala University, Uppsala, Sweden Center for Genomic Medicine, MGH, Boston, MA, USA Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Goteborg, Sweden National Institute for Health and Welfare, Helsinki, Finland Department of Basic and Clinical Neurosciences, King's College London, London, UK Department of Health Care Administration and Management, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan Departments of Neurology & Radiology, Landspitali National University Hospital, Reykjavik, Iceland Department of Neurology, Radiology, and Biomedical Engineering, Washington University School of Medicine, St. Louis, MO, USA Department of Neurology, Heidelberg University Hospital, Heidelberg, Germany Department of Neurology, Erasmus University Medical Center, Rotterdam, the Netherlands Munich Cluster for Systems Neurology (SyNergy), Munich, Germany Hospital Universitari Mutua Terrassa, Terrassa (Barcelona), Spain Centre for Prevention of Stroke and Dementia, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK Department of Medical Sciences, Uppsala University, Uppsala, Sweden BioBank Japan, Laboratory of Clinical Sequencing, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, University of Tokyo, Tokyo, Japan Department of Neurology, Helsinki University Hospital, Helsinki, Finland BioBank Japan, Laboratory of Clinical Sequencing, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, University of Tokyo, Tokyo, Japan Tohoku Medical Megabank Organization, Sendai, Japan Neurovascular Research Laboratory, Vall d'Hebron Institut of Research, Neurology and Medicine Departments-Universitat Autònoma de Barcelona, Vall d'Hebrón Hospital, Barcelona, Spain Department of Neurology, Mayo Clinic, Jacksonville, FL, USA Stroke Pharmacogenomics and Genetics, Fundacio Docència i Recerca MutuaTerrassa, Terrassa, Spain Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany Tohoku Medical Megabank Organization, Sendai, Japan Department of Cerebrovascular Diseases, Fondazione IRCCS Istituto Neurologico 'Carlo Besta', Milan, Italy Department of Neurology, Jagiellonian University, Krakow, Poland Department of Clinical and Experimental Sciences, Neurology Clinic, University of Brescia, Brescia, Italy Translational Genomics Unit, Department of Oncology, IRCCS Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy Department of Genetics, Microbiology and Statistics, University of Barcelona, Barcelona, Spain Neurovascular Research Laboratory, Vall d'Hebron Institut of Research, Neurology and Medicine Departments-Universitat Autònoma de Barcelona, Vall d'Hebrón Hospital, Barcelona, Spain Psychiatric Genetics Unit, Group of Psychiatry, Mental Health and Addictions, Vall d'Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona, Biomedical Network Research Centre on Mental Health (CIBERSAM), Barcelona, Spain Iwate Tohoku Medical Megabank Organization, Iwate Medical University, Iwate, Japan Geriatrics Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, MD, USA Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan Iwate Tohoku Medical Megabank Organization, Iwate Medical University, Iwate, Japan BHF Glasgow Cardiovascular Research Centre, Faculty of Medicine, Glasgow, UK Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan Department of Neurology, Helsinki University Hospital, Helsinki, Finland deCODE Genetics/Amgen, Inc., Reykjavik, Iceland Icelandic Heart Association, Reykjavik, Iceland Iwate Tohoku Medical Megabank Organization, Iwate Medical University, Iwate, Japan IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg, Goteborg, Sweden Institute of Cardiovascular and Medical Sciences, Faculty of Medicine, University of Glasgow, Glasgow, UK deCODE genetics/AMGEN Inc., Reykjavik, Iceland Memory Impairment and Neurodegenerative Dementia Center, University of Mississippi Medical Center, Jackson, MS, USA Tohoku Medical Megabank Organization, Sendai, Japan Iwate Tohoku Medical Megabank Organization, Iwate Medical University, Iwate, Japan Institute for Community Medicine, SHIP-KEF, University Medicine Greifswald, Greifswald, Germany Department of Neurology, Helsinki University Hospital, Helsinki, Finland Stroke Pharmacogenomics and Genetics, Fundacio Docència i Recerca MutuaTerrassa, Terrassa, Spain Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands Landspitali University Hospital, Reykjavik, Iceland Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands Clinical Neurosciences, Neurology, University of Helsinki, Helsinki, Finland Institute for Community Medicine, SHIP-KEF, University Medicine Greifswald, Greifswald, Germany Division of Geriatrics, School of Medicine, University of Mississippi Medical Center, Jackson, MS, USA Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan Department of Clinical Sciences, Lund University, Malmö, Sweden Department of Pathology and Genetics, Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden Albrecht Kossel Institute, University Clinic of Rostock, Rostock, Germany Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK INSERM U1219 Bordeaux Population Health Research Center, University of Bordeaux, France Department of Neurology, Helsinki University Hospital, Helsinki, Finland MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK Data Tecnica International, Glen Echo, MD, USA Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA Department of Neurology, Miller School of Medicine, University of Miami, Miami, FL, USA Department of Pediatrics, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA Department of Epidemiology and Population Health, Albert Einstein College of Medicine, New York, NY, USA Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, USA Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA Cardiovascular Research Center, MGH, Boston, MA, USA Department of Cardiology, Ealing Hospital NHS Trust, Southall, UK Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands Seattle Epidemiologic Research and Information Center, VA Office of Research and Development, Seattle, WA, USA Group Health Research Institute, Group Health Cooperative, Seattle, WA, USA Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, USA Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA Division of Emergency Medicine, and Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA Department of Internal Medicine and the Center for Clinical and Translational Science, Ohio State University, Columbus, OH, USA Montefiore Medical Center, Albert Einstein College of Medicine, New York, NY, USA Department of Epidemiology and Biostatistics, Imperial College London, London, UK Wake Forest School of Medicine, Wake Forest, NC, USA Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA Neuroscience Institute, SF Medical Center, Trenton, NJ, USA Department of Epidemiology, University of Maryland School of Medicine, Baltimore, MD, USA Survey Research Center, University of Michigan, Ann Arbor, MI, USA Department of Neurology, University of Virginia, Charlottesville, VA, USA Department of Biostatistics, University of Washington, Seattle, WA, USA Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA University of Cincinnati College of Medicine, Cincinnati, OH, USA Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA ICAN Institute for Cardiometabolism and Nutrition, Paris, France Departments of Neurology and Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, USA Department of Neurology, University of Maryland School of Medicine and Baltimore VAMC, Baltimore, MD, USA University of Kentucky College of Public Health, Lexington, KY, USA University of Newcastle and Hunter Medical Research Institute, New Lambton, New South Wales, Australia Centre for Brain Research, Indian Institute of Science, Bangalore, India Department of Human Genetics, McGill University, Montreal, Quebec, Canada Department of Neurology, Medical University of Graz, Graz, Austria Department of Neurology, University of Washington, Seattle, WA, USA Hero DMC Heart Institute, Dayanand Medical College & Hospital, Ludhiana, India John Hunter Hospital, Hunter Medical Research Institute and University of Newcastle, Newcastle, New South Wales, Australia UPMC Univ. Paris 06, INSERM, UMR_S 1166, Team Genomics & Pathophysiology of Cardiovascular Diseases, Sorbonne Universités, Paris, France Department of Epidemiology, University of Washington, Seattle, WA, USA University of Technology Sydney, Faculty of Health, Ultimo, New South Wales, Australia Division of Neurology, Faculty of Medicine, Brain Research Center, University of British Columbia, Vancouver, British Columbia, Canada Faculty of Health and Medicine, University of Newcastle, Newcastle, New South Wales, Australia Public Health Stream, Hunter Medical Research Institute, New Lambton, New South Wales, Australia Broad Institute, Cambridge, MA, USA Framingham Heart Study, Framingham, MA, USA Department of Neurology, Austin Health, Heidelberg, Victoria, Australia Stroke Division, Florey Institute of Neuroscience and Mental Health, University of Melbourne, Heidelberg, Victoria, Australia Estonian Genome Center, University of Tartu, Tartu, Estonia Department of Neurology, Massachusetts General Hospital (MGH), Harvard Medical School, Boston, MA, USA Department of Neurology, Caen University Hospital, Caen, France Department of Epidemiology, Nagoya University Graduate School of Medicine, Nagoya, Japan Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA University of Caen Normandy, Caen, France IBE, Faculty of Medicine, LMU Munich, Munich, Germany THL-National Institute for Health and Welfare, Helsinki, Finland FIMM-Institute for Molecular Medicine Finland, Helsinki, Finland Division of Health and Social Care Research, King's College London, London, UK Clinical Gene Networks AB, Stockholm, Sweden National Institute for Health Research Comprehensive Biomedical Research Centre, Guy's & St. Thomas' NHS Foundation Trust and King's College London, London, UK IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain Department of Neurology, IMIM-Hospital del Mar, and Universitat Autònoma de Barcelona, Barceloina, Spain MEB, Karolinska Institutet, Stockholm, Sweden Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany Department of Medicine I, Ludwig-Maximilians-Universität, Munich, Germany Department of Cardiac Surgery, Tartu University Hospital, Tartu, Estonia Department of Pathophysiology, Institute of Biomedicine and Translation Medicine, University of Tartu, Tartu, Estonia Center for Medical Systems Biology, Leiden, the Netherlands Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands Department of Public Health, Bordeaux University Hospital, Bordeaux, France INSERM, U1219, Bordeaux, France Department of Neurology, Institute for Neurodegenerative Disease, Bordeaux University Hospital, Bordeaux, France Sahlgrenska University Hospital, Gothenburg, Sweden Department of Clinical Neurosciences/Neurology, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden Cardiovascular Health Research Unit, Departments of Biostatistics and Medicine, University of Washington, Seattle, WA, USA Department of Allergy and Rheumatology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK Brain Center Rudolf Magnus, Department of Neurology, University Medical Center Utrecht, Utrecht, the Netherlands Clinical Research Facility, Department of Medicine, NUI Galway, Galway, Ireland Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada Department of Neurology and Rehabilitation Medicine, Skåne University Hospital, Lund, Sweden Department of Clinical Sciences Lund, Neurology, Lund University, Lund, Sweden Northern Institute for Cancer Research, Newcastle University, Newcastle, UK SGDP Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK Departments of Medicine, Pediatrics and Population Health Science, University of Mississippi Medical Center, Jackson, MS, USA Department of Medical and Molecular Genetics, King's College London, London, UK VIB Center for Brain & Disease Research, University Hospitals Leuven, Department of Neurology, Leuven, Belgium Department of Neurosciences, Experimental Neurology, KU Leuven-University of Leuven, Leuven, Belgium FIMM-Institute for Molecular Medicine Finland, Helsinki, Finland National Institute for Health and Welfare, Helsinki, Finland Faculty of Medicine, University of Iceland, Reykjavik, Iceland Icelandic Heart Association Research Institute, Kopavogur, Iceland Neurorehabilitation Unit, University of Basel and University Center for Medicine of Aging and Rehabilitation Basel, Felix Platter Hospital, Basel, Switzerland Department of Neurology and Stroke Center, Basel University Hospital, Basel, Switzerland Stroke Pharmacogenomics and Genetics, Fundacio Docència i Recerca MutuaTerrassa, Terrassa, Spain Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO, USA Neurovascular Research Laboratory, Vall d'Hebron Institut of Research, Neurology and Medicine Departments-Universitat Autònoma de Barcelona, Vall d'Hebrón Hospital, Barcelona, Spain National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, UK MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK Centre Hospitalier Université Lille, Epidemiology and Public Health Department, Lille, France INSERM, Institut Pasteur de Lille, LabEx DISTALZ-UMR1167, Risk Factors and Molecular Determinants of Aging-Related Diseases, Université Lille, Lille, France Department of Radiology and Nuclear Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands Laboratory of Statistical Immunology, Immunology Frontier Research Center (WPI-IFReC), Osaka University, Suita, Japan Department of Statistical Genetics, Osaka University Graduate School of Medicine, Osaka, Japan Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan Department of Psychiatry, Hope Center Program on Protein Aggregation and Neurodegeneration (HPAN), Washington University School of Medicine, St. Louis, MO, USA Department of Neurology, Institute for Neurodegenerative Disease, Bordeaux University Hospital, Bordeaux, France Stroke Research Group, Division of Clinical Neurosciences, University of Cambridge, Cambridge, UK NIHR Blood and Transplant Research Unit in Donor Health and Genomics, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK Wellcome Trust Centre for Human Genetics, Oxford, UK Genetic and Genomic Epidemiology Unit, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK Integrated Cardio Metabolic Centre, Department of Medicine, Karolinska Institutet, Karolinska Universitetssjukhuset, Huddinge, Sweden Department of Pathophysiology, Institute of Biomedicine and Translation Medicine, Biomeedikum, University of Tartu, Tartu, Estonia Department of Medical Research, Bærum Hospital, Vestre Viken Hospital Trust, Gjettum, Norway Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA Department of Genetics, University of North Carolina, Chapel Hill, NC, USA National Heart, Lung and Blood Research Institute, Division of Intramural Research, Population Sciences Branch, Framingham, MA, USA Department of Genetics and Genomic Sciences, Icahn Institute for Genomics and Multiscale Biology Icahn School of Medicine at Mount Sinai, New York, NY, USA Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA Department of Neurology, Mayo Clinic Rochester, Rochester, MN, USA Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, San Antonio, TX, USA Oklahoma Center for Neuroscience, Oklahoma City, OK, USA Department of Pharmaceutical Sciences, College of Pharmacy, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA Beth Israel Deaconess Medical Center, Boston, MA, USA Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA Boston University School of Public Health, Boston, MA, USA |
Issue Date: | 2018 | Date: | 2018 | Publication information: | Nature genetics 2018; 50(4): 524-537 | Abstract: | Stroke has multiple etiologies, but the underlying genes and pathways are largely unknown. We conducted a multiancestry genome-wide-association meta-analysis in 521,612 individuals (67,162 cases and 454,450 controls) and discovered 22 new stroke risk loci, bringing the total to 32. We further found shared genetic variation with related vascular traits, including blood pressure, cardiac traits, and venous thromboembolism, at individual loci (n = 18), and using genetic risk scores and linkage-disequilibrium-score regression. Several loci exhibited distinct association and pleiotropy patterns for etiological stroke subtypes. Eleven new susceptibility loci indicate mechanisms not previously implicated in stroke pathophysiology, with prioritization of risk variants and genes accomplished through bioinformatics analyses using extensive functional datasets. Stroke risk loci were significantly enriched in drug targets for antithrombotic therapy. | URI: | https://ahro.austin.org.au/austinjspui/handle/1/20814 | DOI: | 10.1038/s41588-018-0058-3 | ORCID: | 0000-0001-6624-8621 0000-0002-0311-8472 0000-0003-3223-885X 0000-0001-6888-1404 0000-0003-3687-2508 0000-0002-0473-0241 0000-0001-9088-234X 0000-0002-9501-600X 0000-0002-0276-2899 0000-0001-8081-428X 0000-0001-5894-0351 0000-0002-4787-8959 0000-0003-0372-8585 0000-0002-3246-8359 0000-0001-5165-4408 0000-0002-8249-8476 0000-0002-9267-7988 0000-0002-7315-7899 0000-0002-2502-3669 0000-0003-2749-1279 0000-0002-3658-1375 0000-0002-7892-8808 0000-0002-8586-5614 0000-0002-8141-0284 0000-0001-9084-7800 0000-0002-6141-4712 0000-0001-5267-6756 0000-0002-2067-0533 0000-0002-2713-686X 0000-0002-7511-5684 0000-0003-3185-5661 0000-0002-7531-2354 0000-0001-6193-020X 0000-0001-8748-5597 0000-0002-0654-387X 0000-0003-3687-2508 0000-0003-0372-8585 0000-0002-7315-7899 0000-0002-2502-3669 0000-0002-6614-8417 |
Journal: | Nature genetics | PubMed URL: | 29531354 | Type: | Journal Article |
| Appears in Collections: | Journal articles |
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