Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/20786
Title: Multidisciplinary home-based rehabilitation in inoperable lung cancer: a randomised controlled trial.
Austin Authors: Edbrooke, Lara;Aranda, Sanchia;Granger, Catherine L ;McDonald, Christine F ;Krishnasamy, Mei;Mileshkin, Linda;Clark, Ross A;Gordon, Ian;Irving, Louis;Denehy, Linda
Affiliation: School of Health Sciences, The University of Melbourne, Parkville, Victoria, Australia
Allied Health Service, The Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
Department of Medical Oncology, The Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Victoria, Australia
Department of Nursing and Centre for Cancer Research, The University of Melbourne, Parkville, Victoria, Australia
Victorian Comprehensive Cancer Centre, Melbourne, Victoria, Australia
Department of Respiratory and Sleep Medicine, Austin Health, Heidelberg, Victoria, Australia
Department of Medicine, The University of Melbourne, Parkville, Victoria, Australia
Cancer Council Australia, Sydney, New South Wales, Australia
Department of Nursing, The University of Melbourne, Parkville, Victoria, Australia
Department of Physiotherapy, The University of Melbourne, Parkville, Victoria, Australia
Department of Physiotherapy, Royal Melbourne Hospital, Parkville, Victoria, Australia
University of the Sunshine Coast, Sippy Downs, Queensland, Australia
Statistical Consulting Centre, The University of Melbourne, Parkville, Victoria, Australia
Department of Respiratory and Sleep Medicine, Royal Melbourne Hospital, Melbourne, Victoria, Australia
Issue Date: 2019
metadata.dc.date: 2019-05-02
Publication information: Thorax 2019; 74(8): 787-796
Abstract: Lung cancer is associated with poor health-related quality of life (HRQoL) and high symptom burden. This trial aimed to assess the efficacy of home-based rehabilitation versus usual care in inoperable lung cancer. A parallel-group, assessor-blinded, allocation-concealed, randomised controlled trial. Eligible participants were allocated (1:1) to usual care (UC) plus 8 weeks of aerobic and resistance exercise with behaviour change strategies and symptom support (intervention group (IG)) or UC alone. Assessments occurred at baseline, 9 weeks and 6 months. The primary outcome, change in between-group 6 min walk distance (6MWD), was analysed using intention-to-treat (ITT). Subsequent analyses involved modified ITT (mITT) and included participants with at least one follow-up outcome measure. Secondary outcomes included HRQoL and symptoms. Ninety-two participants were recruited. Characteristics of participants (UC=47, IG=45): mean (SD) age 64 (12) years; men 55%; disease stage n (%) III=35 (38) and IV=48 (52); radical treatment 46%. There were no significant between-group differences for the 6MWD (n=92) at 9 weeks (p=0.308) or 6 months (p=0.979). The mITT analyses of 6MWD between-group differences were again non-significant (mean difference (95% CI): 9 weeks: -25.4 m (-64.0 to 13.3), p=0.198 and 6 months: 41.3 m (-26.7 to 109.4), p=0.232). Significant 6-month differences, favouring the IG, were found for HRQoL (Functional Assessment of Cancer Therapy-Lung: 13.0 (3.9 to 22.1), p=0.005) and symptom severity (MD Anderson Symptom Inventory-Lung Cancer: -2.2 (-3.6 to -0.9), p=0.001). Home-based rehabilitation did not improve functional exercise capacity but there were improvements in patient-reported exploratory secondary outcomes measures observed at 6 months. Australian New Zealand Clinical Trials Registry (ACTRN12614001268639).
URI: http://ahro.austin.org.au/austinjspui/handle/1/20786
DOI: 10.1136/thoraxjnl-2018-212996
ORCID: 0000-0002-4149-5578
0000-0001-6481-3391
0000-0001-6169-370X
PubMed URL: 31048509
Type: Journal Article
Subjects: exercise
non-small cell lung cancer
Appears in Collections:Journal articles

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