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Title: Oxygen compared to air during exercise training in COPD with exercise-induced desaturation.
Austin Authors: Alison, Jennifer A;McKeough, Zoe J;Leung, Regina W M;Holland, Anne E ;Hill, Kylie;Morris, Norman R;Jenkins, Sue;Spencer, Lissa M;Hill, Catherine J ;Lee, Annemarie L;Seale, Helen;Cecins, Nola;McDonald, Christine F 
Affiliation: The University of Sydney, Faculty of Health Sciences, Discipline of Physiotherapy, Sydney, Australia
Concord Repatriation General Hospital, Sydney, Australia
Sydney Local Health District, Sydney, Australia
Institute for Breathing and Sleep
Respiratory and Sleep Medicine
Department of Physiotherapy, Sir Charles Gardiner Hospital, Perth, Australia
Department of Physiotherapy, Prince Charles Hospital, Queensland, Australia
School of Allied Health, La Trobe University, Melbourne, Australia
School of Physiotherapy and Exercise Science, Faculty of Health Sciences, Curtin University, Perth, Australia
Institute for Respiratory Health, Sir Charles Gairdner Hospital, Perth, Australia
School of Allied Health Sciences, Griffith University, Southport, Australia
Metro North Hospital and Health Service, The Prince Charles Hospital, Allied Health Research Collaborative, Brisbane, Australia
Discipline of Physiotherapy, School of Allied Health, LaTrobe University, Melbourne, Australia
Department of Physiotherapy, Alfred Health, Melbourne, Australia
Department of Physiotherapy, Royal Prince Alfred Hospital, Sydney, Australia
Issue Date: 30-May-2019
Date: 2019-03-17
Publication information: European Respiratory Journal 2019; 53(5): 1802429
Abstract: Almost half the patients referred to pulmonary rehabilitation with chronic obstructive pulmonary disease (COPD) desaturate during exercise. Although oxygen supplementation may ameliorate oxygen desaturation, the effects on outcomes of exercise training have not been rigorously evaluated. The study aimed to determine whether supplemental oxygen during exercise training was more effective than medical air in improving exercise capacity and health-related quality of life in people with COPD.People with COPD who demonstrated oxygen desaturation <90% during the six-minute walk test were recruited to this multi-centre trial with randomisation (independent, concealed allocation) to either an Oxygen Group or Air Group, blinding (participants, exercise trainers and European Respiratory Journal assessors) and intention-to-treat analysis. Both groups received the respective gas from concentrators via nasal prongs at five litres/min during exercise training consisting of treadmill and cycle exercise, three times/week for eight weeks. Primary outcomes were the endurance shuttle walk test (ESWT) and Chronic Respiratory Disease Questionnaire total score (CRQ-Total).111 participants (60 males), mean (sd) age 69 (7) years, with moderate to severe COPD were recruited and 97 completed (Oxygen Group n=52; Air Group n=45). At the end of the 8-week training there were no between-group differences in change in ESWT (mean difference [95% Confidence Interval] 15 s [-106-136] or change in CRQ-Total (0.0 points [-0.3-0.3]). Within-group changes at end-training were significant for ESWT and CRQ-Total (all p<0.01).Exercise capacity and health-related quality of life improved in both groups, with no greater benefit from training with supplemental oxygen than medical air.
DOI: 10.1183/13993003.02429-2018
ORCID: 0000-0001-6481-3391
Journal: European Respiratory Journal
PubMed URL: 30880289
Type: Journal Article
Appears in Collections:Journal articles

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