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Title: Epidermal growth factor receptor (EGFR)-targeted therapies in Mesothelioma.
Austin Authors: Chia, Puey Ling ;Scott, Andrew M ;John, Thomas 
Affiliation: Faculty of Medicine, University of Melbourne, Melbourne, Australia
School of Cancer Medicine, La Trobe University, Melbourne, Australia
Department of Molecular Imaging and Therapy, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australia
Department of Medical Oncology, Austin Health, Heidelberg, Victoria, Australia
Olivia Newton-John Cancer Research Institute, Heidelberg, Victoria, Australia
Issue Date: 27-Mar-2019 2019-03-27
Publication information: Expert opinion on drug delivery 2019; 16(4): 441-451
Abstract: Malignant mesothelioma (MM) is an aggressive malignancy arising from the mesothelial cells lining the pleura and other serosal membranes. It is associated with an extremely poor prognosis and has limited therapeutic options. Areas covered: Epidermal growth factor receptor (EGFR) is known to be highly over-expressed in mesothelioma with reported EGFR overexpression between 44 to 97%. Given this, several anti-EGFR agents have been trialled in mesothelioma. In this review, we provide an overview of the current available data on anti-EGFR therapies in MM and future directions of investigation with these targeted agents in MM. Expert opinion: While many anti-EGFR therapies have failed to show significant efficacy in the management of MM, the pathway is biologically active and its abrogation preclinically points towards it being a valid target. Towards targeting the pathway, many novel EGFR based therapies are still being investigated. Current ongoing research of interest in MM include EGFR targeted nanotechnology approach for drug delivery, antibodies targeting the extracellular EGFR and potentially anti-EGFR antibody drug conjugates.
DOI: 10.1080/17425247.2019.1598374
ORCID: 0000-0002-6656-295X
PubMed URL: 30916586
Type: Journal Article
Subjects: EGFR overexpression
epidermal growth factor receptor (EGFR)
malignant mesothelioma
targeted therapies
Appears in Collections:Journal articles

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