Sodium intake, circulating microvesicles and cardiovascular outcomes in type 2 diabetes.

2019-02-12

Liu, Dorothy

Baqar, Sara

Lincz, Lisa L

Ekinci, Elif I

Cardiovascular disease

endothelial dysfunction

endothelial microvesicles

sodium intake

twenty four hour urinary sodium excretion

type two diabetes

Journal Article

0000-0002-4921-1349

0000-0003-2372-395X

#PLACEHOLDER_PARENT_METADATA_VALUE#

#PLACEHOLDER_PARENT_METADATA_VALUE#

10.2174/1573399815666190212120822

There is ongoing debate surrounding the complex relationship between dietary sodium intake and cardiovascular morbidity and mortality. The existing literature consists largely of observational studies that have demonstrated positive, negative, U-/J-shaped or unclear associations between sodium intake and cardiovascular outcomes. Our group and others have previously demonstrated an inverse relationship between dietary sodium intake and cardiovascular outcomes in people with type 2 diabetes. Increased activity of the renin-angiotensin-aldosterone system and sympathetic nervous system are postulated to contribute to these paradoxical findings through endothelial dysfunction, a precursor to the development of cardiovascular disease. Microvesicles are submicron (0.1 - 1.0µm) vesicles that form during cellular activation, injury or death with endothelial microvesicles being recognized markers of endothelial dysfunction. They are pathologically elevated in a variety of vascular-related conditions including type 2 diabetes. Lower habitual sodium intake in type 2 diabetes has been associated with higher pro-coagulant platelet microvesicles levels but not with endothelial microvesicles. Research utilizing endothelial microvesicles to evaluate the mechanistic relationship between dietary sodium intake and adverse cardiovascular outcomes in type 2 diabetes remains scarce.

link

Current Diabetes Reviews 2019; 15(6): 435-445

Current Diabetes Reviews