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Title: Sodium intake, circulating microvesicles and cardiovascular outcomes in type 2 diabetes.
Austin Authors: Liu, Dorothy ;Baqar, Sara;Lincz, Lisa L;Ekinci, Elif I 
Affiliation: Department of Medicine, Austin Health, Heidelberg, Victoria, Australia
Hunter Haematology Research Group, Calvary Mater Newcastle, New South Wales. Austria
Department of Medicine, Austin Health, Heidelberg, Victoria, Australia
Issue Date: 12-Feb-2019 2019-02-12
Publication information: Current diabetes reviews 2019; 15(6): 435-445
Abstract: There is ongoing debate surrounding the complex relationship between dietary sodium intake and cardiovascular morbidity and mortality. The existing literature consists largely of observational studies that have demonstrated positive, negative, U-/J-shaped or unclear associations between sodium intake and cardiovascular outcomes. Our group and others have previously demonstrated an inverse relationship between dietary sodium intake and cardiovascular outcomes in people with type 2 diabetes. Increased activity of the renin-angiotensin-aldosterone system and sympathetic nervous system are postulated to contribute to these paradoxical findings through endothelial dysfunction, a precursor to the development of cardiovascular disease. Microvesicles are submicron (0.1 - 1.0µm) vesicles that form during cellular activation, injury or death with endothelial microvesicles being recognized markers of endothelial dysfunction. They are pathologically elevated in a variety of vascular-related conditions including type 2 diabetes. Lower habitual sodium intake in type 2 diabetes has been associated with higher pro-coagulant platelet microvesicles levels but not with endothelial microvesicles. Research utilizing endothelial microvesicles to evaluate the mechanistic relationship between dietary sodium intake and adverse cardiovascular outcomes in type 2 diabetes remains scarce.
DOI: 10.2174/1573399815666190212120822
ORCID: 0000-0002-4921-1349
PubMed URL: 30747074
Type: Journal Article
Subjects: Cardiovascular disease
endothelial dysfunction
endothelial microvesicles
sodium intake
twenty four hour urinary sodium excretion
type two diabetes
Appears in Collections:Journal articles

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