Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/20278
Title: Effects of sustained cognitive activity on white matter microstructure and cognitive outcomes in healthy middle-aged adults: A systematic review.
Austin Authors: McPhee, Grace M;Downey, Luke A;Stough, Con
Affiliation: Institute for Breathing and Sleep, Austin Health, Heidelberg, Victoria, Australia
Centre for Human Psychopharmacology, Swinburne University of Technology, Melbourne, Australia
Issue Date: 22-Feb-2019
metadata.dc.date: 2019-05
Publication information: Ageing research reviews 2019; 51: 35-47
Abstract: Adults who remain cognitively active may be protected from age-associated changes in white matter (WM) and cognitive decline. To determine if cognitive activity is a precursor for WM plasticity, the available literature was systematically searched for Region of Interest (ROI) and whole-brain studies assessing the efficacy of cognitive training (CT) on WM microstructure using Diffusion Tensor Imaging (DTI) in healthy adults (> 40 years). Seven studies were identified and included in this review. Results suggest there are beneficial effects to WM microstructure after CT in frontal and medial brain regions, with some studies showing improved performance in cognitive outcomes. Benefits of CT were shown to be protective against age-related WM microstructure decline by either maintaining or improving WM after training. These results have implications for determining the capacity for training-dependent WM plasticity in older adults and whether CT can be utilised to prevent age-associated cognitive decline. Additional studies with standardised training and imaging protocols are needed to confirm these outcomes.
URI: http://ahro.austin.org.au/austinjspui/handle/1/20278
DOI: 10.1016/j.arr.2019.02.004
PubMed URL: 30802543
Type: Journal Article
Subjects: Aging
Cognitive training
Diffusion tensor imaging
Neuroplasticity
White matter
Appears in Collections:Journal articles

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