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Title: Outcome and safety of targeted liver biopsies for indeterminate lesions in patients with chronic liver disease: A single centre experience.
Austin Authors: Chen, Xiao ;Kutaiba, Numan ;Ngo, Brian ;Goodwin, Mark D 
Affiliation: Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, Victoria, Australia
Department of Radiology, Austin Health, Heidelberg, Victoria, Australia
Issue Date: Apr-2019
Date: 2019-01-16
Publication information: Journal of Medical Imaging and Radiation Oncology 2019; 63(2): 190-196
Abstract: To evaluate the histopathological and safety outcomes of indeterminate lesions in patients at high risk for developing hepatocellular carcinoma (HCC) who underwent ultrasound-guided biopsies. Ultrasound-guided targeted liver biopsies for indeterminate lesions performed in a 10-year period at our institution were reviewed retrospectively for lesion characteristics, biopsy techniques, histopathological results and post procedural complications. A total of 172 biopsies were performed in 152 patients. Most common background liver disease included hepatitis C, hepatitis B, alcoholic and non-alcoholic steatohepatitis. 65.1% had known cirrhosis at time of biopsy. HCC was the most common histopathological finding accounting for 55.8% of all biopsies, followed by cholangiocarcinoma, dysplastic nodule and metastasis. Rarer lesions including lymphoma, neuroendocrine tumour and angiomyolipoma were also encountered. No mortality, clinically significant bleeding or tumour seeding was detected. Ultrasound-guided liver biopsies of indeterminate lesions in patients at high risk of HCC yield important histopathological findings, important for management options including the provision of curative treatments and assisting future novel therapies such as immunotherapy and targeted therapies. The low complication rates confirm its safety and the procedure should not be avoided for fear of complications.
DOI: 10.1111/1754-9485.12856
ORCID: 0000-0001-9486-0850
Journal: Journal of Medical Imaging and Radiation Oncology
PubMed URL: 30652433
Type: Journal Article
Subjects: chronic liver disease
hepatocellular carcinoma
liver biopsies
Appears in Collections:Journal articles

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