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Title: An Overlooked Brain Region in the Aetiology of Anorexia Nervosa: The Importance of Behaviourally Driven Neuroimaging Analysis.
Austin Authors: Phillipou, Andrea ;Castle, David J;Abel, Larry A A;Gurvich, Caroline;Rossell, Susan L
Affiliation: Department of Mental Health, Austin Health, Heidelberg, Victoria, Australia
Monash Alfred Psychiatry Research Centre, Monash University and The Alfred Hospital, Melbourne, Victoria, Australia
Department of Optometry and Vision Sciences, The University of Melbourne, Melbourne, Victoria, Australia
Department of Psychiatry, The University of Melbourne, Melbourne, Victoria, Australia
Centre for Mental Health, Swinburne University of Technology, Hawthorn, Victoria, Australia
Department of Mental Health, St Vincent's Hospital, Melbourne, Melbourne, Victoria, Australia
Issue Date: 20-Dec-2018
Date: 2018
Publication information: Journal of experimental neuroscience 2018; 12: 1179069518820068
Abstract: The neurobiological contributions to anorexia nervosa (AN) remain poorly understood, hindering the development of effective neurobiological treatments such as medications and brain stimulation. A large number of studies have been undertaken utilising neuroimaging techniques, such as magnetic resonance imaging (MRI), to gain a better understanding of the brain mechanisms involved in the illness. However, the analyses undertaken by many studies have utilised a whole-brain analytical approach as much of this research has been exploratory in nature. This is, however, problematic as small brain regions that differ between groups may not have the statistical power to produce statistically significant results. This is highlighted in a recent study undertaken by our group utilising diffusion-weighted imaging. In this research, we identified widespread white matter microstructural differences in individuals with AN, but only showed differences in a small brain region (the superior colliculus) when a region-of-interest approach that was driven by behavioural findings was utilised. The importance of hypothesis-driven neuroimaging analyses is discussed in this article.
DOI: 10.1177/1179069518820068
ORCID: 0000-0003-1009-6619
Journal: Journal of experimental neuroscience
PubMed URL: 30626999
ISSN: 1179-0695
Type: Journal Article
Subjects: Anorexia nervosa
diffusion-weighted imaging
Magnetic Resonance Imaging
superior colliculus
Appears in Collections:Journal articles

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