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Title: A body shape index (ABSI) reflects body composition changes in response to testosterone treatment in obese men.
Austin Authors: Hoermann, Rudolf;Ng Tang Fui, Mark ;Krakauer, Jesse C;Krakauer, Nir Y;Grossmann, Mathis 
Affiliation: Department of Medicine, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australia
Department of Endocrinology, Austin Health, Heidelberg, Victoria, Australia
Metro Detroit Diabetes and Endocrinology, Southfield, MI, USA
Department of Civil Engineering, City College of New York, New York, NY, USA
Issue Date: 2019
Date: 2019-01-08
Publication information: International journal of obesity (2005) 2019; 43(11): 2210-2216
Abstract: Interventions such as testosterone treatment may change body composition and metabolic outcomes without substantial changes in weight and BMI. Using testosterone treatment as a paradigm, we hypothesized that a body shape index (ABSI) reflects body composition changes more accurately than traditional markers, such as weight, BMI and waist circumference. Secondary analysis of a 56-week RCT in 100 dieting obese men with low-normal testosterone receiving testosterone treatment or placebo, and subsequent off-treatment follow-up. At the end of the trial period, ABSI-unlike weight, BMI or waist circumference-had significantly decreased in the treatment group, compared with placebo (mean adjusted difference -0.18 [95% CI: -0.32, -0.05] × 10-2 m11/6kg-2/3, overall P<0.001). Changes in ABSI during the active trial phase correlated with changes in fat mass (tau = 0.18, P = 0.02), and not with lean mass (tau = -0.11, P = 0.14), BMI (tau = 0.10, P = 0.17), or visceral fat (tau = 0.07, P = 0.37). ABSI baseline values were positively correlated with waist circumference (tau = 0.21, P = 0.002) and visceral fat (tau = 0.18, P = 0.009), correlated inversely with lean mass (tau = -0.21, P = 0.002), and were uncorrelated with BMI (tau = -0.10, P = 0.15) and fat mass (tau = 0.01, P = 0.83). Two years after cessation of treatment, ABSI again reflected body composition as the between-group differences in all parameters did not persist. A readily obtainable anthropomorphic measure, ABSI reflects the differential loss of fat mass mediated by testosterone in dieting obese men more closely than BMI or waist circumference. It may serve as a clinically useful marker to monitor body composition changes, particularly in response to interventions.
DOI: 10.1038/s41366-018-0311-y
ORCID: 0000-0002-1326-4270
Journal: International journal of obesity (2005)
PubMed URL: 30622310
Type: Journal Article
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