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Title: The Effect of a High-Dose Vitamin B Multivitamin Supplement on the Relationship between Brain Metabolism and Blood Biomarkers of Oxidative Stress: A Randomized Control Trial.
Austin Authors: Ford, Talitha C;Downey, Luke A;Simpson, Tamara;McPhee, Grace;Oliver, Chris;Stough, Con
Affiliation: Centre for Human Psychopharmacology, Swinburne University, Melbourne, VIC 3122, Australia
Institute for Breathing and Sleep, Austin Health, Heidelberg, Victoria, Australia
Oliver Nutrition, Sydney, NSW 2000, Australia
Issue Date: 1-Dec-2018
Date: 2018-12-01
Publication information: Nutrients 2018; 10(12): E1860
Abstract: A diet rich in B-group vitamins is essential for optimal body and brain function, and insufficient amounts of such vitamins have been associated with higher levels of neural inflammation and oxidative stress, as marked by increased blood plasma homocysteine. Neural biomarkers of oxidative stress quantified through proton magnetic spectroscopy (1H-MRS) are not well understood, and the relationship between such neural and blood biomarkers is seldom studied. The current study addresses this gap by investigating the direct effect of 6-month high-dose B-group vitamin supplementation on neural and blood biomarkers of metabolism. Using a randomized, double-blind, placebo-controlled design, 32 healthy adults (20 female, 12 male) aged 30⁻65 years underwent blood tests (vitamin B6, vitamin B12, folate, and homocysteine levels) and 1H-MRS of the posterior cingulate cortex (PCC) and dorsolateral prefrontal cortex (DLPFC) before and after supplementation. Results confirmed the supplement was effective in increasing vitamin B6 and vitamin B12 levels and reducing homocysteine, whereas there was no change in folate levels. There were significant relationships between vitamin B6 and N-acetylaspartate (NAA), choline, and creatine, as well as between vitamin B12 and creatine (ps < 0.05), whereas NAA in the PCC increased, albeit not significantly (p > 0.05). Together these data provide preliminary evidence for the efficacy of high-dose B-group supplementation in reducing oxidative stress and inflammation through increasing oxidative metabolism. It may also promote myelination, cellular metabolism, and energy storage.
DOI: 10.3390/nu10121860
ORCID: 0000-0003-1182-4841
Journal: Nutrients
PubMed URL: 30513795
Type: Journal Article
Subjects: 1H-MRS
B vitamins
oxidative stress
posterior cingulate cortex
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