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Title: The Safety and Efficacy of an Oral Penicillin Challenge Program in Cancer Patients: A Multicenter Pilot Study.
Austin Authors: Trubiano, Jason A ;Smibert, Olivia;Douglas, Abby;Devchand, Misha ;Lambros, Belinda;Holmes, Natasha E ;Chua, Kyra Y L ;Phillips, Elizabeth J;Slavin, Monica A
Affiliation: Department of Medicine, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australia
The National Centre for Infections in Cancer, Department of Infectious Diseases, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
Centre for Antibiotic Allergy and Research, Austin Health, Heidelberg, Victoria, Australia
Department of Infectious Diseases, Austin Health, Heidelberg, Victoria, Australia
Department of Infectious Diseases, Vanderbilt University Medical Centre, Nashville, Tennessee
Issue Date: Dec-2018 2018-11-17
Publication information: Open forum infectious diseases 2018; 5(12): ofy306
Abstract: Antibiotic allergies are reported by up to 1 in 4 cancer patients, almost 50% of which are considered low risk and precede the cancer diagnosis. We demonstrate the successful and safe implementation of a pilot oral penicillin challenge program for cancer patients with low-risk penicillin allergies, increasing the use of penicillin and narrow-spectrum beta-lactams post-testing.
DOI: 10.1093/ofid/ofy306
ORCID: 0000-0002-5111-6367
PubMed URL: 30547046
ISSN: 2328-8957
Type: Journal Article
Subjects: beta-lactam allergy
immunocompromised host
oral challenge
oral provocation
penicillin allergy
Appears in Collections:Journal articles

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