An international perspective on hospitalized patients with viral community-acquired pneumonia.

2018-11-03

Radovanovic, Dejan

Sotgiu, Giovanni

Jankovic, Mateja

Mahesh, Padukudru Anand

Marcos, Pedro Jorge

Abdalla, Mohamed I

Di Pasquale, Marta Francesca

Gramegna, Andrea

Terraneo, Silvia

Blasi, Francesco

Santus, Pierachille

Borderìas, Luis

Bordon Garcia, Noel Manuel

Cabello Alarcón, Hugo

Cilloniz, Catia

Torres, Antoni

Diaz-Brito, Vicens

Casas, Xavier

Encabo González, Alicia

Fernández-Almira, Maria Luisa

Cambursano, Victor Hugo

Jayaraj, B S

Gallego, Miguel

Gaspar-GarcÍa, Inmaculada

González Del Castillo, Juan

Javaloyes Victoria, Patricia

Laserna Martínez, Elena

Malo de Molina, Rosa

Menéndez, Rosario

Pando-Sandoval, Ana

Prat Aymerich, Cristina

Lacoma de la Torre, Alicia

Narayan, Kiran Vishnu

Ceccato, Adrian

García-Olivé, Ignasi

Rello, Jordi

Moyano, Silvia

Sanz, Francisco

Sibila, Oriol

Rodrigo-Troyano, Ana

Solé-Violán, Jordi

Uranga, Ane

van Boven, Job F M

Udnur, Hirennappa B

Vendrell Torra, Ester

Chertcoff, Julio

Pujol, Jordi Almirall

Feldman, Charles

Kee Yum, Ho

Fiogbe, Arnauld Attannon

Yangui, Ferdaous

Bilaceroglu, Semra

Dalar, Levent

Yilmaz, Ufuk

Krishnamurthy, Shashi Bhaskara

Bogomolov, Artemii

Elahi, Naheed

Cordon Díaz, Ariel

Dhasmana, Devesh J

Feneley, Andrew

Hancock, Carole

Hill, Adam T

Rudran, Banu

Ruiz-Buitrago, Silvia

Campbell, Marion

Kant, Surya

Whitaker, Paul

Youzguin, Alexander

Singanayagam, Anika

de Vedia, Lautaro

Allen, Karen S

Brito, Veronica

Dietz, Jessica

Dysart, Claire E

Kellie, Susan M

Franco-Sadud, Ricardo A

Swarnakar, Rajesh

Meier, Garnet

Gaga, Mina

Holland, Thomas L

Bergin, Stephen P

Ganaha, Maria Cristina

Kheir, Fayez

Landmeier, Mark

Lois, Manuel

Nair, Girish B

Patel, Hemali

Salvi, Sundeep

Reyes, Katherine

Rodriguez-Cintron, William

Saito, Shigeki

Soni, Nilam J

Noda, Julio

Lambert, Sandra

Hinojosa, Cecilia I

Levine, Stephanie M

Angel, Luis F

Anzueto, Antonio

Limaye, Sneha

Scott Whitlow, K

Hipskind, John

Sukhija, Kunal

Totten, Vicken

Wunderink, Richard G

Shah, Ray D

Lopardo, Gustavo

Mateyo, Kondwelani John

Carugati, Manuela

Morosi, Manuela

Golshani, Keihan

Monge, Elisa

Luna, Carlos M

Malberti, Alessio Gerardo

Morcillo, Nora

Tartara, Silvina

Pensotti, Claudia

Pereyra, Betiana

Scapellato, Pablo Gustavo

Stagnaro, Juan Pablo

Shah, Sonali

Keatings, Vera M

Lötsch, Felix

Thalhammer, Florian

Anseeuw, Kurt

Francois, Camille A

Van Braeckel, Eva

Vincent, Jean Louis

Djimon, Marcel Zannou

Aranha Nouér, Simone

Chipev, Peter

Encheva, Milena

Aliberti, Stefano

Miteva, Darina

Petkova, Diana

Balkissou, Adamou Dodo

Pefura Yone, Eric Walter

Mbatchou Ngahane, Bertrand Hugo

Shen, Ning

Xu, Jin-Fu

Bustamante Rico, Carlos Andres

Buitrago, Ricardo

Pereira Paternina, Fernando Jose

Martin-Loeches, Ignacio

Kayembe Ntumba, Jean-Marie

Vladic-Carevic, Vesna

Jakopovic, Marko

Matkovic, Zinka

Mitrecic, Ivan

Bouchy Jacobsson, Marie-Laure

Bro Christensen, Anette

Heitmann Bødtger, Uffe Christian

Meyer, Christian Niels

Vestergaard Jensen, Andreas

Maor, Yasmin

El-Said Abd El-Wahhab, Ibrahim

Elsayed Morsy, Nesreen

Shafiek, Hanaa

Sobh, Eman

Abdulsemed, Kedir Abdella

Bertrand, Fabrice

Brun-Buisson, Christian

de Montmollin, Etienne

Fartoukh, Muriel

Messika, Jonathan

Strahilevitz, Jacob

Tattevin, Pierre

Khoury, Abdo

Ebruke, Bernard

Dreher, Michael

Kolditz, Martin

Meisinger, Matthias

Pletz, Mathias W

Hagel, Stefan

Rupp, Jan

Schaberg, Tom

Battaglia, Salvatore

Spielmanns, Marc

Creutz, Petra

Suttorp, Norton

Siaw-Lartey, Beatrice

Dimakou, Katerina

Papapetrou, Dimosthenis

Tsigou, Evdoxia

Ampazis, Dimitrios

Kaimakamis, Evangelos

Bhatia, Mohit

Carrabba, Maria

Dhar, Raja

D'Souza, George

Garg, Rajiv

Koul, Parvaiz A

Ceriana, Piero

Confalonieri, Marco

d'Arminio Monforte, Antonella

Del Prato, Bruno

De Rosa, Marino

Reyes, Luis F

Fantini, Riccardo

Fiorentino, Giuseppe

Gammino, Maria Antonia

Menzella, Francesco

Milani, Giuseppe

Nava, Stefano

Palmiero, Gerardo

Petrino, Roberta

Gabrielli, Barbra

Rossi, Paolo

Restrepo, Marcos I

Sorino, Claudio

Steinhilber, Gundi

Zanforlin, Alessandro

Franzetti, Fabio

Carone, Mauro

Patella, Vincenzo

Scarlata, Simone

Comel, Andrea

Kurahashi, Kiyoyasu

Aoun Bacha, Zeina

Aruj, Patricia Karina

Barajas Ugalde, Daniel

Ceballos Zuñiga, Omar

Villegas, José F

Medenica, Milic

van de Garde, E M W

Raj Mihsra, Deebya

Shrestha, Poojan

Ridgeon, Elliott

Ishola Awokola, Babatunde

Nwankwo, Ogonna N O

Attorri, Silvia

Olufunlola, Adefuye Bolanle

Olumide, Segaolu

Ukwaja, Kingsley N

Irfan, Muhammad

Minarowski, Lukasz

Szymon, Skoczyński

Froes, Felipe

Leuschner, Pedro

Meireles, Mariana

Ferrão, Cláudia

Barimboim, Enrique

Neves, João

Ravara, Sofia B

Brocovschii, Victoria

Ion, Chesov

Rusu, Doina

Toma, Cristina

Chirita, Daniela

Dorobat, Carmen Mihaela

Birkun, Alexei

Kaluzhenina, Anna

Caeiro, Juan Pablo

Almotairi, Abdullah

Bukhary, Zakeya Abdulbaqi Ali

Edathodu, Jameela

Fathy, Amal

Mushira Abdulaziz Enani, Abdullah

Eltayeb Mohamed, Nazik

Ulhadi Memon, Jawed

Bella, Abdelhaleem

Bogdanović, Nada

Milenkovic, Branislava

Garzón, María I

Pesut, Dragica

Community acquired pneumonia

Influenza

Oseltamivir

Testing

Viral pneumonia

Viral swab

Journal Article

10.1016/j.ejim.2018.10.020

Who should be tested for viruses in patients with community acquired pneumonia (CAP), prevalence and risk factors for viral CAP are still debated. We evaluated the frequency of viral testing, virus prevalence, risk factors and treatment coverage with oseltamivir in patients admitted for CAP. Secondary analysis of GLIMP, an international, multicenter, point-prevalence study of hospitalized adults with CAP. Testing frequency, prevalence of viral CAP and treatment with oseltamivir were assessed among patients who underwent a viral swab. Univariate and multivariate analysis was used to evaluate risk factors. 553 (14.9%) patients with CAP underwent nasal swab. Viral CAP was diagnosed in 157 (28.4%) patients. Influenza virus was isolated in 80.9% of cases. Testing frequency and viral CAP prevalence were inhomogeneous across the participating centers. Obesity (OR 1.59, 95%CI: 1.01-2.48; p = 0.043) and need for invasive mechanical ventilation (OR 1.62, 95%CI: 1.02-2.56; p = 0.040) were independently associated with viral CAP. Prevalence of empirical treatment with oseltamivir was 5.1%. In an international scenario, testing frequency for viruses in CAP is very low. The most common cause of viral CAP is Influenza virus. Obesity and need for invasive ventilation represent independent risk factors for viral CAP. Adherence to recommendations for treatment with oseltamivir is poor.

link

European journal of internal medicine 2018; online first: 3 November

European journal of internal medicine