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Title: The Outcome of Acetaminophen-Induced Acute Liver Failure managed without Intracranial Pressure Monitoring or Transplantation.
Austin Authors: Porteous, Jennifer;Cioccari, Luca;Ancona, Paolo;Osawa, Eduardo A;Jones, Kelly;Gow, Paul J ;Angus, Peter W ;Warrillow, Stephen J ;Bellomo, Rinaldo 
Affiliation: Victorian Liver Transplant Unit, Austin Health, Heidelberg, Victoria, Australia
Department of Intensive Care, Austin Health, Heidelberg, Victoria, Australia
Department of Intensive Care Medicine, University Hospital University of Bern, Switzerland
Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine Monash University, Prahran, Victoria, Australia
Issue Date: 31-Oct-2018 2018-10-31
Publication information: Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 2018; online first: 31 October
Abstract: Acetaminophen-induced acute liver failure (ALF) may require emergency liver transplantation (LT) in the presence of specific criteria, and its management may also include intracranial pressure (ICP) monitoring in selected patients at high risk of cerebral edema. We aimed to test the hypothesis that management of such patients without ICP monitoring or LT would yield outcomes similar to those reported with conventional management. We interrogated a database of all patients treated in ICU for acetaminophen-induced ALF between November 2010 and October 2016 and obtained relevant information from electronic medical records. We studied 64 patients (58 females) with a median age of 38 years. Such patients had a high prevalence of depression, substance abuse or other psychiatric disorders and had ingested a median acetaminophen dose of 25g. No patient received ICP monitoring or LT. Overall, 51 (79.7%) patients survived. Of the 42 patients who met King's College Hospital (KCH) criteria, 29 (69.1%) survived without transplantation. Forty-five patients developed severe hepatic encephalopathy, and 32 (71.1%) of these survived. Finally, compared to KCH criteria, the current UK registration criteria (UKRC) for super-urgent LT had better sensitivity (92.3%) and specificity (80.4%) for hospital mortality. In a center applying a no ICP monitoring and no LT approach to the management of acetaminophen-induced ALF, over six years, overall survival was 79.7% and for patients fulfilling KCH criteria 69.1%, both higher than for equivalent patients treated with conventional management as reported in the literature. Finally, the current UKRC may be a better predictor of hospital mortality in this patient population. This article is protected by copyright. All rights reserved.
DOI: 10.1002/lt.25377
ORCID: 0000-0002-1650-8939
PubMed URL: 30379388
Type: Journal Article
Subjects: Acetaminophen
acute liver failure
drug overdose
liver transplantation
Appears in Collections:Journal articles

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