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Title: A Randomized Controlled Trial of Adherence to a 24-Month Home-Based Physical Activity Program and the Health Benefits for Older Adults at Risk of Alzheimer's Disease: The AIBL Active-Study.
Austin Authors: Cox, Kay L;Cyarto, Elizabeth V;Ellis, Kathryn A;Ames, David;Desmond, Patricia;Phal, Pramit;Sharman, Matthew J;Szoeke, Cassandra;Rowe, Christopher C ;Masters, Colin L ;You, Emily;Burrows, Sally;Lai, Michelle M Y;Lautenschlager, Nicola T
Affiliation: Medical School University of Western Australia, Perth, Australia
The Florey Institute, The University of Melbourne, Australia
School of Health Sciences, University of Tasmania, Launceston, Tasmania, Australia
Academic Unit for Psychiatry of Old Age, Department of Psychiatry, The University of Melbourne, Kew, Victoria, Australia
WA Centre for Health & Ageing, University of Western Australia, Perth, Australia
Department of Molecular Imaging and Therapy, Austin Health, Heidelberg, Victoria, Australia
Department of Medicine (Royal Melbourne Hospital), University of Melbourne, Melbourne, Australia
Department of Radiology, Royal Melbourne Hospital, University of Melbourne, Australia
Bolton Clarke Research Institute, Melbourne, Australia
Epworth Medical Imaging, Richmond, Victoria, Australia
School of Psychology, Australian Catholic University, Melbourne, Australia
Melbourne Dementia Research Centre, University of Melbourne, Melbourne, Australia
NorthWestern Mental Health, Melbourne Health, Melbourne, Australia
Issue Date: 2019 2018-10-26
Publication information: Journal of Alzheimer's disease : JAD 2019; 70(s1): S187-S205
Abstract: Previous studies have demonstrated that physical activity (PA) interventions can improve physical and cognitive outcomes in older adults, but most have been relatively short in duration (<1 year) with a few having specifically targeting individuals at risk of developing Alzheimer's disease. To examine adherence and physical health outcomes in a 24-month home-based PA intervention in older adults at risk of Alzheimer's disease. Participants 60 years and older with mild cognitive impairment (MCI) or subjective memory complaints (SMC) with at least 1 cerebrovascular risk factor recruited from The Australian Imaging Biomarkers and Lifestyle Flagship Study of Aging (AIBL) were randomized to a PA or control group (nā€Š=ā€Š106). The control group continued with their usual lifestyle. The PA group received a 24-month home-based program with a target of 150 minutes/week of moderate PA and a behavioral intervention. Retention (participants remaining) and PA adherence (PA group only, percent PA completed to the PA prescribed) were determined at 6, 12, 18, and 24 months. Assessments at baseline, 6, 12, and 24 months included, PA; fitness; body composition and fat distribution. Key outcome measures were PA adherence and PA. The 24-month retention rate (97.2%) and the median PA adherence 91.67% (Q1-Q3, 81.96, 100.00) were excellent. In the long-term the intervention group achieved significantly better improvements in PA levels, leg strength, fat mass and fat distribution compared to the control. This study demonstrates that in this target group, long-term PA adherence is achievable and has physical health benefits.
DOI: 10.3233/JAD-180521
ORCID: 0000-0003-3910-2453
Journal: Journal of Alzheimer's disease : JAD
PubMed URL: 30372680
Type: Journal Article
Subjects: Adherence
cerebrovascular disease
mild cognitive impairment
physical activity
subjective memory complaints
Appears in Collections:Journal articles

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