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Title: Bilateral facial nerve palsies secondary to chronic inflammatory demyelinating polyneuropathy following adalimumab treatment
Austin Authors: Yao, Anthony ;Chan, Helen;Macdonell, Richard A L ;Shuey, Neil;Khong, Jwu Jin
Affiliation: Austin Health, Heidelberg, Victoria, Australia
The Royal Victorian Eye and Ear Hospital, East Melbourne, Victoria, Australia
Centre for Eye Research Australia, Department of Surgery, University of Melbourne, East Melbourne, Victoria, Australia
Issue Date: Jan-2018 2017-11-22
Publication information: Clinical Neurology and Neurosurgery 2018; 164: 64-66
Abstract: PURPOSE: Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) presents uncommonly with cranial nerve involvement with ophthalmological implications. METHODS: We report the case of a 37year-old man who developed CIDP which manifested as progressive and relapsing bilateral facial nerve palsy with lagophthalmos and exposure keratopathy, in the setting of treatment of Crohn's disease with the anti-TNF-alpha agent adalimumab. RESULTS: Symptoms gradually improved over the course of several months following withdrawal of adalimumab and treatment with intravenous immunoglobulin (IVIg) and oral prednisolone. CONCLUSION: Bilateral facial nerve involvement occurs uncommonly as a feature of CIDP in its classic form. The prognosis is good for recovery of facial nerve function with discontinuation of anti-TNF-alpha therapy and concurrent use of steroid and intravenous immunoglobulin in this case.
DOI: 10.1016/j.clineuro.2017.11.001
ORCID: 0000-0003-3838-8795
PubMed URL:
Type: Journal Article
Subjects: Adalimumab
Chronic inflammatory demyelinating polyneuropathy
Type of Clinical Study or Trial: Case Series and Case Reports
Appears in Collections:Journal articles

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