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Title: Orbital tuberculosis: perspectives from Victoria, Australia
Austin Authors: Yao, Anthony ;Aboltins, Craig;McNab, Alan A.;Salinas-La Rosa, Cesar;Denholm, Justin;Khong, Jwu Jin
Affiliation: The Royal Victorian Eye and Ear Hospital, East Melbourne, Victoria, Australia
Victorian Tuberculosis Program, Melbourne Health, Victoria, Australia
St Vincent’s Hospital, Fitzroy, Victoria, Australia
Austin Health, Heidelberg, Victoria, Australia
Centre for Eye Research Australia, East Melbourne, Victoria, Australia
Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Australia
Issue Date: 18-Aug-2018
Publication information: Graefe's Archive for Clinical and Experimental Ophthalmology 2018; online first: 18 August
Abstract: Purpose: Orbital tuberculosis (TB) is a rare extra-pulmonary manifestation of tuberculosis and its clinical diagnosis poses unique challenges, with potential for destructive complications as well as social and public health implications. The aim of this study is to report our experience of patients presenting with orbital TB and to identify common aspects. Methods: A systematic search for mandatory notifications of orbital tuberculosis between January 01, 1994 and December 12, 2016 was undertaken in the Victorian Tuberculosis database. In addition, members of the Australian and New Zealand Society of Ophthalmic Plastic Surgeons (ANZSOPS) were surveyed to identify cases of orbital tuberculosis diagnosed on biopsy in the past 20 years. Medical case notes of identified cases were reviewed retrospectively. Results: Three cases were identified as having occurred in Victoria, aged 44–59 years old. All cases had emigrated from endemic countries with higher tuberculosis burden. Diagnosis of tuberculosis was often difficult due to few or non-viable acid fast bacilli and low yield of positive culture in paucicellular orbital specimens. Conclusions: Orbital TB is rare but remains an important differential diagnosis of orbital mass lesions. The diagnosis of orbital TB requires a high index of clinical suspicion and targeted investigations in patients originating from endemic areas. Diagnosis and treatment rely on effective collaboration between ophthalmologists, infectious disease physicians, and pathologists.
DOI: 10.1007/s00417-018-4099-1
ORCID: 0000-0003-3838-8795
Journal: Graefe's Archive for Clinical and Experimental Ophthalmology
PubMed URL:
Type: Journal Article
Subjects: orbit
orbital mass
mycobacterium tuberculosis
Type of Clinical Study or Trial: Case Series and Case Reports
Appears in Collections:Journal articles

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