Circulating concentrations of B group vitamins and urothelial cell carcinoma.

2018-10-14

Bassett, Julie K

Brinkman, Maree T

Dugué, Pierre-Antoine

Ueland, Per M

Midttun, Øivind

Ulvik, Arve

Bolton, Damien M

Southey, Melissa C

English, Dallas R

Milne, Roger L

Hodge, Allison M

Giles, Graham G

B vitamins

Melbourne Collaborative Cohort Study

bladder cancer

urothelial cell carcinoma

Journal Article

0000-0003-0799-4821

0000-0002-5145-6783

0000-0001-5464-2197

10.1002/ijc.31927

B-group vitamins, as components of the one carbon metabolism pathway, are involved in DNA synthesis, repair and methylation. Our aim was to investigate associations between circulating plasma levels of B vitamins and urothelial cell carcinoma (UCC). We conducted a nested case-control study of UCC within the Melbourne Collaborative Cohort Study. B vitamins were measured in pre-diagnostic plasma samples. Conditional logistic regression was used to estimate odds ratios (OR) for UCC risk associated with circulating B vitamins in 363 matched cases and controls. In a case-only analysis (N = 390), hazard ratios (HR) for overall survival associated with plasma B vitamins were estimated using Cox regression. There were no strong associations between UCC risk and pre-diagnostic levels of plasma B vitamins. No heterogeneity in UCC risk was observed by subtype (invasive or superficial), sex, smoking status or alcohol intake. There was no heterogeneity by country of birth for most B vitamins, except for folate (P-homogeneity = 0.03). In UCC cases, there were no strong associations between plasma B vitamins and overall survival. We found no associations between pre-diagnostic plasma concentrations of B-group vitamins and UCC risk or survival. This article is protected by copyright. All rights reserved.

link

International journal of cancer 2019; 144(8): 1909-1917

International journal of cancer