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Title: Circulating concentrations of B group vitamins and urothelial cell carcinoma.
Austin Authors: Bassett, Julie K;Brinkman, Maree T;Dugué, Pierre-Antoine;Ueland, Per M;Midttun, Øivind;Ulvik, Arve;Bolton, Damien M ;Southey, Melissa C;English, Dallas R;Milne, Roger L;Hodge, Allison M;Giles, Graham G
Affiliation: Bevital AS, Bergen, Norway
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Parkville, Victoria, 3052, Australia
Precision Medicine, School of Clinical Sciences, Monash University, Clayton, Victoria, 3168, Australia
Genetic Epidemiology Laboratory, Department of Pathology, University of Melbourne, Melbourne, Victoria, 3000, Australia
Cancer Epidemiology and Intelligence Division, Cancer Council Victoria, Melbourne, Victoria, 3004, Australia
Department of Clinical Science, University of Bergen, Bergen, Norway
Laboratory of Clinical Biochemistry, Haukeland University Hospital, Bergen, Norway
Department of Surgery, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australia
Issue Date: 14-Oct-2018 2018-10-14
Publication information: International journal of cancer 2019; 144(8): 1909-1917
Abstract: B-group vitamins, as components of the one carbon metabolism pathway, are involved in DNA synthesis, repair and methylation. Our aim was to investigate associations between circulating plasma levels of B vitamins and urothelial cell carcinoma (UCC). We conducted a nested case-control study of UCC within the Melbourne Collaborative Cohort Study. B vitamins were measured in pre-diagnostic plasma samples. Conditional logistic regression was used to estimate odds ratios (OR) for UCC risk associated with circulating B vitamins in 363 matched cases and controls. In a case-only analysis (N = 390), hazard ratios (HR) for overall survival associated with plasma B vitamins were estimated using Cox regression. There were no strong associations between UCC risk and pre-diagnostic levels of plasma B vitamins. No heterogeneity in UCC risk was observed by subtype (invasive or superficial), sex, smoking status or alcohol intake. There was no heterogeneity by country of birth for most B vitamins, except for folate (P-homogeneity = 0.03). In UCC cases, there were no strong associations between plasma B vitamins and overall survival. We found no associations between pre-diagnostic plasma concentrations of B-group vitamins and UCC risk or survival. This article is protected by copyright. All rights reserved.
DOI: 10.1002/ijc.31927
ORCID: 0000-0003-0799-4821
PubMed URL: 30318764
Type: Journal Article
Subjects: B vitamins
Melbourne Collaborative Cohort Study
bladder cancer
urothelial cell carcinoma
Appears in Collections:Journal articles

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