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Title: Clinical trial participation by adolescents and young adults with cancer: A continued cause for concern?
Austin Authors: White, Victoria;Skaczkowski, Gemma ;Anazodo, Antoinette;Bibby, Helen;Nicholls, Wayne;Pinkerton, Ross;Thompson, Kate;Orme, Lisa M;Conyers, Rachel;Osborn, Michael;Phillips, Marianne B;Harrup, Rosemary;Walker, Rick;Coory, Michael
Affiliation: Nelune Comprehensive Cancer Center, Prince of Wales Hospital, Randwick, NSW, Australia
Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, VIC, Australia
Princess Alexandra Hospital, Woolloongabba, QLD, Australia
Center for Behavioural Research in Cancer, Cancer Council Victoria, Melbourne, VIC, Australia
Olivia Newton-John Cancer Wellness and Research Centre, Austin Health, Heidelberg, Victoria, Australia
School of Women's and Children's Health University of New South Wales, NSW, Australia
Children's Cancer Center, The Royal Children's Hospital, Parkville, VIC, Australia
Kids Cancer Center, Sydney Children's Hospital, Randwick, NSW, Australia
Princess Margaret Hospital for Children, Subiaco, WA, Australia
Royal Hobart Hospital, Hobart, TAS, Australia
Peter MacCallum Cancer Center, Melbourne, VIC, Australia
School of Psychology and Public Health, La Trobe University, Melbourne, VIC, Australia
School of Psychology, Deakin University, Geelong, VIC, Australia
Children's Health Queensland Hospital and Health Service, South Brisbane QLD, Australia
Murdoch Childrens Research Institute, Royal Children's Hospital, Parkville, VIC, Australia
Royal Adelaide Hospital, Adelaide, SA, Australia
Issue Date: 2018 2018-04-30
Publication information: Seminars in oncology 2018; 45(5-6): 275-283
Abstract: International data indicate that rates of clinical trial enrolment for Adolescents and Young Adults (AYAs) with cancer are markedly lower than for any other age group. This paper reviews the recent literature reporting international trends in clinical trial enrolment since 2010. Subsequently, we present the first population-based, national assessment of clinical trial enrolment for AYAs with cancer in Australia. Reported rates of trial enrolment from Australia, Canada, the United States, and the United Kingdom were variable, though consistently low, ranging between 2% and 29%. Trial enrolment was higher for younger AYAs (typically 15-19 years) and those attending pediatric hospitals, and this was replicated in the recent Australian data. The findings highlight a lack of substantial improvement in AYA clinical trial enrolment and in particular, a need for improved opportunities to access trials for patients treated at adult centers.
DOI: 10.1053/j.seminoncol.2018.04.002
ORCID: 0000-0003-0715-3563
PubMed URL: 30327126
Type: Journal Article
Subjects: AYA
Adolescents and young adults
Clinical trials
Appears in Collections:Journal articles

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