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https://ahro.austin.org.au/austinjspui/handle/1/19646| Title: | Clinical trial participation by adolescents and young adults with cancer: A continued cause for concern? | Austin Authors: | White, Victoria;Skaczkowski, Gemma ;Anazodo, Antoinette;Bibby, Helen;Nicholls, Wayne;Pinkerton, Ross;Thompson, Kate;Orme, Lisa M;Conyers, Rachel;Osborn, Michael;Phillips, Marianne B;Harrup, Rosemary;Walker, Rick;Coory, Michael | Affiliation: | Nelune Comprehensive Cancer Center, Prince of Wales Hospital, Randwick, NSW, Australia Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, VIC, Australia Princess Alexandra Hospital, Woolloongabba, QLD, Australia Center for Behavioural Research in Cancer, Cancer Council Victoria, Melbourne, VIC, Australia Olivia Newton-John Cancer Wellness and Research Centre, Austin Health, Heidelberg, Victoria, Australia School of Women's and Children's Health University of New South Wales, NSW, Australia Children's Cancer Center, The Royal Children's Hospital, Parkville, VIC, Australia Kids Cancer Center, Sydney Children's Hospital, Randwick, NSW, Australia Princess Margaret Hospital for Children, Subiaco, WA, Australia Royal Hobart Hospital, Hobart, TAS, Australia Peter MacCallum Cancer Center, Melbourne, VIC, Australia School of Psychology and Public Health, La Trobe University, Melbourne, VIC, Australia School of Psychology, Deakin University, Geelong, VIC, Australia Children's Health Queensland Hospital and Health Service, South Brisbane QLD, Australia Murdoch Childrens Research Institute, Royal Children's Hospital, Parkville, VIC, Australia Royal Adelaide Hospital, Adelaide, SA, Australia |
Issue Date: | 2018 | Date: | 2018-04-30 | Publication information: | Seminars in oncology 2018; 45(5-6): 275-283 | Abstract: | International data indicate that rates of clinical trial enrolment for Adolescents and Young Adults (AYAs) with cancer are markedly lower than for any other age group. This paper reviews the recent literature reporting international trends in clinical trial enrolment since 2010. Subsequently, we present the first population-based, national assessment of clinical trial enrolment for AYAs with cancer in Australia. Reported rates of trial enrolment from Australia, Canada, the United States, and the United Kingdom were variable, though consistently low, ranging between 2% and 29%. Trial enrolment was higher for younger AYAs (typically 15-19 years) and those attending pediatric hospitals, and this was replicated in the recent Australian data. The findings highlight a lack of substantial improvement in AYA clinical trial enrolment and in particular, a need for improved opportunities to access trials for patients treated at adult centers. | URI: | https://ahro.austin.org.au/austinjspui/handle/1/19646 | DOI: | 10.1053/j.seminoncol.2018.04.002 | ORCID: | 0000-0003-0715-3563 | Journal: | Seminars in oncology | PubMed URL: | 30327126 | Type: | Journal Article | Subjects: | AYA Adolescents and young adults Cancer Clinical trials |
| Appears in Collections: | Journal articles |
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