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Title: Differences in cancer survival by sex: a population-based study using cancer registry data.
Austin Authors: Afshar, Nina;English, Dallas R;Thursfield, Vicky;Mitchell, Paul L R ;Te Marvelde, Luc;Farrugia, Helen;Giles, Graham G;Milne, Roger L
Affiliation: Cancer Strategy and Development, Department of Health and Human Services, Melbourne, Victoria, Australia
Cancer Epidemiology and Intelligence Division, Cancer Council Victoria, Melbourne, Victoria, Australia
Centre for Epidemiology and Biostatistics, School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia
Department of Medical Oncology, Olivia Newton-John Cancer Wellness and Research Centre, Austin Health, Heidelberg, Victoria, Australia
Victorian Cancer Registry, Cancer Council Victoria, Melbourne, Victoria, Australia
Issue Date: 7-Sep-2018 2018-09-07
Publication information: Cancer causes & control : CCC 2018; 29(11): 1059-1069
Abstract: Few large-scale studies have investigated sex differences in cancer survival and little is known about their temporal and age-related patterns. We used cancer registry data for first primary cancers diagnosed between 1982 and 2015 in Victoria, Australia. Cases were followed until the end of 2015 through linkage to death registries. Differences in survival were assessed for 25 cancers using the Pohar-Perme estimator of net survival and the excess mortality rate ratio (EMRR) adjusting for age and year of diagnosis. Five-year net survival for all cancers combined was lower for men (47.1%; 95% CI 46.9-47.4) than women (52.0%; 95% CI 51.7-52.3); EMRR 1.13 (95% CI 1.12-1.14; pā€‰<ā€‰0.001). A survival disadvantage for men was observed for 11 cancers: head and neck, esophagus, colorectum, pancreas, lung, bone, melanoma, mesothelioma, kidney, thyroid, and non-Hodgkin lymphoma. In contrast, women had lower survival from cancers of the bladder, renal pelvis, and ureter. For the majority of cancers with survival differences, the EMRR decreased with increasing age at diagnosis; for colorectal, esophageal, and kidney cancer, the EMRR increased with time since diagnosis. Identifying the underlying reasons behind sex differences in cancer survival is necessary to address inequalities, which may improve outcomes for men and women.
DOI: 10.1007/s10552-018-1079-z
ORCID: 0000-0001-5587-9540
PubMed URL: 30194549
Type: Journal Article
Subjects: Cancer registries
Cancer survival
Excess mortality
Sex differences
Survival analysis
Appears in Collections:Journal articles

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