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Title: Beyond Penicillin: Rapid Desensitization for Specific Flucloxacillin Hypersensitivity.
Austin Authors: Kwong, Jason C ;Urbancic, Karen F ;Trubiano, Jason A 
Affiliation: National Centre for Infections in Cancer, Peter MacCallum Cancer Centre, Victoria, Australia
Department of Infectious Diseases, Austin Health, Heidelberg, Victoria, Australia
Pharmacy Department, Austin Health, Heidelberg, Victoria, Australia
Centre for Antibiotic Allergy and Research, Department of Infectious Diseases, Austin Health, Heidelberg, Victoria, Australia
Issue Date: Dec-2018 2018-11-26
Publication information: Antimicrobial agents and chemotherapy 2018; 62(1): e01371-18
Abstract: Beta-lactam therapy for severe staphylococcal infections is associated with superior outcomes when compared to non-beta-lactam therapy. In patients with immediate hypersensitivity to beta-lactams, desensitization has been widely employed to allow beta-lactam therapy, but published protocols for anti-staphylococcal beta-lactams such as flucloxacillin are lacking. Here, we report a case and the desensitization protocol successfully used for a patient with isolated flucloxacillin immediate hypersensitivity, where a penicillin desensitization protocol would likely have resulted in an adverse drug reaction.
DOI: 10.1128/AAC.01371-18
ORCID: 0000-0002-5111-6367
Journal: Antimicrobial agents and chemotherapy
PubMed URL: 30224537
Type: Journal Article
Appears in Collections:Journal articles

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