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Title: Systematic Review: An Update on the Spectrum of Urological Malignancies in Lynch Syndrome.
Austin Authors: Huang, Dora;Matin, Surena F;Lawrentschuk, Nathan;Roupret, Morgan
Affiliation: Sorbonne Université, GRC n° 5, ONCOTYPE-URO, AP-HP, Hôpital Pitié-Salpêtrière, F-75013 Paris, France
Department of Surgery, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australia
Department of Urology, MD Anderson Cancer Center, Houston, TX, USA
Olivia Newton-John Cancer Wellness and Research Centre, Austin Health, Heidelberg, Victoria, Australia
Division of Cancer Surgery, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
Issue Date: 30-Jul-2018 2018
Publication information: Bladder cancer (Amsterdam, Netherlands) 2018; 4(3): 261-268
Abstract: Lynch syndrome is an autosomal dominant disorder that predisposes individuals affected to certain malignancies. Colon and endometrial cancers are the malignancies most highly associated with Lynch syndrome. However, growing body of evidence links Lynch syndrome to urological cancers. This review aims to clarify the type of urological malignancies that fall under the Lynch-associated cancer spectrum. Using PRISMA guidelines, a systematic search between January 1990 to February 2018, was conducted using the MEDLINE database with the application of the following MESH terms: colorectal neoplasms, hereditary nonpolyposis; DNA mismatch repair; urologic neoplasms; kidney pelvis; ureteral neoplasms; urinary bladder; carcinoma, transitional cell; prostatic neoplasms; testicular neoplasms. Upper tract urothelial cancers are well established under the Lynch spectrum. Increasing evidence supports its association with prostate cancer. However, there is, inconclusive and limited evidence for an association with bladder and testicular cancer. The evidence underpinning certain urological malignancies associated with Lynch syndrome has expanded in recent years. Our review may assist in providing a summary of the current standing in literature. However, we recommend further investigations to better clarify associations, particularly with prostate, bladder and testicular cancer.
DOI: 10.3233/BLC-180180
ORCID: 0000-0001-8553-5618
Journal: Bladder cancer (Amsterdam, Netherlands)
PubMed URL: 30112437
ISSN: 2352-3727
Type: Journal Article
Subjects: Testicular neoplasms
Colorectal neoplasms
DNA mismatch repair
hereditary nonpolyposis
kidney pelvis
prostatic neoplasms
transitional cell
ureteral neoplasms
urinary bladder
urologic neoplasms
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