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Title: Systematic review of structural and functional brain alterations in psychosis of epilepsy.
Austin Authors: Allebone, James;Kanaan, Richard A A ;Wilson, Sarah J
Affiliation: Melbourne School of Psychological Sciences, University of Melbourne, Melbourne, Victoria, Australia
Department of Psychiatry, University of Melbourne, Melbourne, Victoria, Australia
Florey Institute of Neuroscience and Mental Health, Brain Research Institute, Heidelberg, Victoria, Australia
Comprehensive Epilepsy Programme, Austin Health, Melbourne Brain Centre, Heidelberg, Victoria, Australia
Issue Date: Jun-2018 2017-12-23
Publication information: Journal of neurology, neurosurgery, and psychiatry 2018; 89(6): 611-617
Abstract: This systematic review critically assesses structural and functional neuroimaging studies of psychosis of epilepsy (POE). We integrate findings from 18 studies of adults with POE to examine the prevailing view that there is a specific relationship between temporal lobe epilepsy (TLE) and POE, and that mesial temporal lobe pathology is a biomarker for POE. Our results show: (1) conflicting evidence of volumetric change in the hippocampus and amygdala; (2) distributed structural pathology beyond the mesial temporal lobe; and (3) changes in frontotemporal functional network activation. These results provide strong evidence for a revised conceptualisation of POE as disorder of brain networks, and highlight that abnormalities in mesial temporal structures alone are unlikely to account for its neuropathogenesis. Understanding POE as a disease of brain networks has important implications for neuroimaging research and clinical practice. Specifically, we suggest that future neuroimaging studies of POE target structural and functional networks, and that practitioners are vigilant for psychotic symptoms in all epilepsies, not just TLE.
DOI: 10.1136/jnnp-2017-317102
ORCID: 0000-0002-2872-1112
PubMed URL: 29275328
Type: Journal Article
Subjects: Epilepsy
Functional Imaging
Appears in Collections:Journal articles

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