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Title: Features of the broader autism phenotype in people with epilepsy support shared mechanisms between epilepsy and autism spectrum disorder.
Austin Authors: Richard, Annie E;Scheffer, Ingrid E ;Wilson, Sarah J
Affiliation: Melbourne School of Psychological Sciences, The University of Melbourne, Victoria, Australia
Department of Medicine, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australia
The Florey Institute of Neuroscience and Mental Health, Heidelberg, Victoria, Australia
Department of Paediatrics, The University of Melbourne and Department of Neurology, Royal Children's Hospital, Melbourne, Victoria 3084, Australia
Issue Date: Apr-2017
Date: 2017-01-16
Publication information: Neuroscience and biobehavioral reviews 2017; 75: 203-233
Abstract: Features of the broader autism phenotype in people with epilepsy support shared mechanisms between epilepsy and autism spectrum disorder. NEUROSCI BIOBEHAV REV 21(1) XXX-XXX, 2016. To inform on mechanisms underlying the comorbidity of epilepsy and autism spectrum disorder (ASD), we conducted meta-analyses to test whether impaired facial emotion recognition (FER) and theory of mind (ToM), key phenotypic traits of ASD, are more common in people with epilepsy (PWE) than controls. We contrasted these findings with those of relatives of individuals with ASD (ASD-relatives) compared to controls. Furthermore, we examined the relationship of demographic (age, IQ, sex) and epilepsy-related factors (epilepsy onset age, duration, seizure laterality and origin) to FER and ToM. Thirty-one eligible studies of PWE (including 1449 individuals: 77% with temporal lobe epilepsy), and 22 of ASD-relatives (N=1295) were identified by a systematic database search. Analyses revealed reduced FER and ToM in PWE compared to controls (p<0.001), but only reduced ToM in ASD-relatives (p<0.001). ToM was poorer in PWE than ASD-relatives. Only weak associations were found between FER and ToM and epilepsy-related factors. These findings suggest shared mechanisms between epilepsy and ASD, independent of intellectual disability.
DOI: 10.1016/j.neubiorev.2016.12.036
ORCID: 0000-0002-2311-2174
Journal: Neuroscience and biobehavioral reviews
PubMed URL: 28104412
Type: Journal Article
Subjects: Autism spectrum disorder
Broader autism phenotype
Facial emotion recognition
Theory of mind
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