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Title: Mouse models for gastric cancer: Matching models to biological questions.
Austin Authors: Poh, Ashleigh R;O'Donoghue, Robert J J;Ernst, Matthias ;Putoczki, Tracy L
Affiliation: Olivia Newton-John Cancer Research Institute, Heidelberg, Victoria, Australia
Department of Medical Biology, University of Melbourne, Melbourne, Victoria, Australia
School of Cancer Medicine, La Trobe University, Melbourne, Victoria, Australia
The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia
Issue Date: Jul-2016
Publication information: Journal of gastroenterology and hepatology 2016; 31(7): 1257-72
Abstract: Gastric cancer is the third leading cause of cancer-related mortality worldwide. This is in part due to the asymptomatic nature of the disease, which often results in late-stage diagnosis, at which point there are limited treatment options. Even when treated successfully, gastric cancer patients have a high risk of tumor recurrence and acquired drug resistance. It is vital to gain a better understanding of the molecular mechanisms underlying gastric cancer pathogenesis to facilitate the design of new-targeted therapies that may improve patient survival. A number of chemically and genetically engineered mouse models of gastric cancer have provided significant insight into the contribution of genetic and environmental factors to disease onset and progression. This review outlines the strengths and limitations of current mouse models of gastric cancer and their relevance to the pre-clinical development of new therapeutics.
DOI: 10.1111/jgh.13297
ORCID: 0000-0002-6399-1177
PubMed URL: 26809278
Type: Journal Article
Subjects: Helicobacter pylori
diffuse gastric cancer
intestinal-type gastric cancer
mouse model
Appears in Collections:Journal articles

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