Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/19190
Title: Prognostic factors and predictive tools for upper tract urothelial carcinoma: a systematic review.
Austin Authors: Mbeutcha, Aurélie;Roupret, Morgan;Kamat, Ashish M;Karakiewicz, Pierre I;Lawrentschuk, Nathan;Novara, Giacomo;Raman, Jay D;Seitz, Christian;Xylinas, Evanguelos;Shariat, Shahrokh F
Affiliation: Department of Surgical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
Department of Urology, Cochin Hospital, APHP, Paris Descartes University, Paris, France
Department of Urology, University of Montreal Health Center, Montreal, QC, Canada
Department of Surgery, Oncology, and Gastroenterology - Urology Clinic, University of Padua, Padua, Italy
Division of Urology, Penn State Milton S. Hershey Medical Center, Hershey, PA, USA
Department of Urology, University of Nice Sophia-Antipolis, Hôpital Pasteur 2, Centre Hospitalier Universitaire de Nice, Nice, France
Department of Urology, Pitié-Salpétrière Hospital, APHP, University Paris VI, Paris, France
Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna General Hospital, Währinger Gürtel 18-20, 1090, Vienna, Austria
Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX, USA
Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna General Hospital, Währinger Gürtel 18-20, 1090, Vienna, Austria
Department of Urology, Weill Cornell Medical College, New York, NY, USA
Department of Urology, University of Texas MD Anderson Cancer Center, Houston, TX, USA
Department of Surgery, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australia
Olivia Newton-John Cancer Research Institute, Heidelberg, Victoria, Australia
Issue Date: Mar-2017
metadata.dc.date: 2016-04-21
Publication information: World Journal of Urology 2017; 35(3): 337-353
Abstract: Upper tract urothelial carcinoma (UTUC) is a rare and heterogeneous disease. Several clinical and biological prognostic factors have been identified in multi-institutional collaborative works with the aim of helping decision-making in pursuit of tailored individual patient care. This review provides an overview of these existing prognostic factors and predictive tools for the management of patients with UTUC. A systematic literature search was performed using PubMed/MEDLINE, Web of Science and Scopus databases regarding articles published in English between January 2000 and November 2015 according to PRISMA guidelines. Thresholds of 100 and 300 patients were applied for studies on biomarkers and clinical studies, respectively. All the studies on predictive tools were included for analysis. Outcomes of interest were features associated with advanced-stage UTUC, disease recurrence and survival. A total of 116 studies were included in this review. These large and/or multi-institutional studies have confirmed the prognostic value of standard pathological factors (i.e., tumor stage, grade and lymph node metastasis) and identified novel features such as lymphovascular invasion, tumor architecture, multifocality, concomitant CIS, variant histology and biomarker status among others. Based on these variables, several predictive tools have been developed; however, they often lack of validation. The value of these features and tools needs prospective testing. Efforts provided by international collaboration groups have permitted to validate established features and identify new features of biologically and clinically aggressive UTUC. Further investigation on prognostic factors and biomarkers is still needed to assess the benefit of these features and tools on clinical decision-making.
URI: http://ahro.austin.org.au/austinjspui/handle/1/19190
DOI: 10.1007/s00345-016-1826-2
ORCID: 0000-0001-8553-5618
PubMed URL: 27101100
Type: Journal Article
Subjects: Biomarkers
Disease recurrence
Nomograms
Predictive tools
Prognosis
Prognostic factors
Risk stratification
Survival
Upper tract urothelial carcinoma
Appears in Collections:Journal articles

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