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Title: Definition and diagnostic criteria of sleep-related hypermotor epilepsy.
Austin Authors: Tinuper, Paolo;Bisulli, Francesca;Cross, J H;Hesdorffer, Dale;Kahane, Philippe;Nobili, Lino;Provini, Federica;Scheffer, Ingrid E ;Tassi, Laura;Vignatelli, Luca;Bassetti, Claudio;Cirignotta, Fabio;Derry, Christopher;Gambardella, Antonio;Guerrini, Renzo;Halasz, Peter;Licchetta, Laura;Mahowald, Mark;Manni, Raffaele;Marini, Carla;Mostacci, Barbara;Naldi, Ilaria;Parrino, Liborio;Picard, Fabienne;Pugliatti, Maura;Ryvlin, Philippe;Vigevano, Federico;Zucconi, Marco;Berkovic, Samuel F ;Ottman, Ruth
Affiliation: Epilepsy Institute, IDEE, Lyon, France.
Department of Clinical Neurosciences, CHUV, LaUSAnne, Switzerland
Functional Neurology and Epileptology, Hospices Civils de Lyon and CRNL, Lyon
IRCCS Istituto delle Scienze Neurologiche, Bologna
Department of Biomedical and Neuromotor Sciences, University of Bologna, Italy
University College London-Institute of Child Health, Great Ormond Street Hospital for Children NHS Foundation Trust, London and Young Epilepsy, Lingfield, UK
Department of Epidemiology, Mailman School of Public Health, and G.H. Sergievsky Center, College of Physicians & Surgeons, Columbia University, New York, NY
Unité Médicale Epilepsie et Malaises, Pôle de Neurologie et Psychiatrie, CHU de Grenoble, France
"C. Munari" Center for Epilepsy Surgery, Niguarda Hospital, Milan, Italy
Epilepsy Research Centre, Department of Medicine, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australia
Department of Neurology, University of Bern, Switzerland
Unit of Neurology, S. Orsola-Malpighi Hospital, University of Bologna, Italy
Department of Clinical Neurosciences, Western General Hospital, Edinburgh, UK
Department of Medical and Surgical Sciences, Institute of Neurology, University Magna Græcia, Catanzaro, Italy
Neurology Unit and Laboratories, A. Meyer Children's Hospital, Florence, Italy
National Institute of Clinical Neuroscience, Budapest, Hungary
Department of Neurology, University of Minnesota Medical School, Minneapolis
Institute of Neurology Mondino, University of Pavia
Sleep Disorders Center, Department of Neurology, University of Parma, Italy
Department of Neurology, University Hospital and Medical School of Geneva, Switzerland
Department of Biomedical and Surgical Sciences, University of Ferrara, Italy
Issue Date: 10-May-2016
Date: 2016-04-15
Publication information: Neurology 2016; 86(19): 1834-42
Abstract: The syndrome known as nocturnal frontal lobe epilepsy is recognized worldwide and has been studied in a wide range of clinical and scientific settings (epilepsy, sleep medicine, neurosurgery, pediatric neurology, epidemiology, genetics). Though uncommon, it is of considerable interest to practicing neurologists because of complexity in differential diagnosis from more common, benign sleep disorders such as parasomnias, or other disorders like psychogenic nonepileptic seizures. Moreover, misdiagnosis can have substantial adverse consequences on patients' lives. At present, there is no consensus definition of this disorder and disagreement persists about its core electroclinical features and the spectrum of etiologies involved. To improve the definition of the disorder and establish diagnostic criteria with levels of certainty, a consensus conference using formal recommended methodology was held in Bologna in September 2014. It was recommended that the name be changed to sleep-related hypermotor epilepsy (SHE), reflecting evidence that the attacks are associated with sleep rather than time of day, the seizures may arise from extrafrontal sites, and the motor aspects of the seizures are characteristic. The etiology may be genetic or due to structural pathology, but in most cases remains unknown. Diagnostic criteria were developed with 3 levels of certainty: witnessed (possible) SHE, video-documented (clinical) SHE, and video-EEG-documented (confirmed) SHE. The main research gaps involve epidemiology, pathophysiology, treatment, and prognosis.
DOI: 10.1212/WNL.0000000000002666
ORCID: 0000-0002-2311-2174
Journal: Neurology
PubMed URL: 27164717
Type: Conference
Journal Article
Appears in Collections:Journal articles

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