Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/19161
Title: Intra-day variability of cystatin C, creatinine and estimated GFR in intensive care patients.
Austin Authors: Ravn, Bo;Larsson, Anders;Mårtensson, Johan;Martling, Claes-Roland;Bell, Max
Affiliation: Clinical Chemistry, Department of Medical Sciences, Uppsala University, 751 85 Uppsala, Sweden
Section of Anaesthesia and Intensive Care Medicine, Department of Physiology and Pharmacology, Karolinska Institutet, 17176 Stockholm, Sweden
Department of Intensive Care, Austin Health, Heidelberg, Victoria, Australia
Section of Anaesthesia and Intensive Care Medicine, Department of Physiology and Pharmacology, Karolinska Institutet, 17176 Stockholm, Sweden
Issue Date: 1-Sep-2016
metadata.dc.date: 2016-06-14
Publication information: Clinica chimica acta; international journal of clinical chemistry 2016; 460: 1-4
Abstract: Markers of renal function are widely used in intensive care and sudden changes are important indicators of acute kidney injury. The problem is to distinguish between disease progression/improvement from the natural variation in the patient. The aim of the present study was thus to study the normal intraday variation in ICU patients. We studied the intra-day variation of creatinine, cystatin C and estimated GFR based on these two markers in 28 clinically stable ICU patients. The median diurnal coefficient of variation sCV) for creatinine was 3.70% (1.92-9.25%) while the median CV for cystatin C was 3.66% (1.36-8.11%). The corresponding CVs for the estimated GFRs were 2.00% (0.89-9.82%) for eGFRcreatinine and 4.60% (1.65-10.24%) for eGFRcystc. The eGFRcreatinine values in individual patients were clearly higher than the eGFRcystc values. The median CV for creatinine, cystatin C and the eGFR measurements were below 5% which means that 95% of the test results will vary by <10% between sampling times in stable ICU patients. Differences >10% between sampling times are thus likely to be an indication of changes in biomarker levels due to the disease/treatment.
URI: http://ahro.austin.org.au/austinjspui/handle/1/19161
DOI: 10.1016/j.cca.2016.06.014
ORCID: 0000-0001-8739-7896
PubMed URL: 27315745
Type: Journal Article
Subjects: Creatinine
Critical illness
Cystatin C
Renal markers
Appears in Collections:Journal articles

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