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Title: Immunohistochemical Validation of Spontaneously Arising Canine Osteosarcoma as a Model for Human Osteosarcoma.
Austin Authors: Al-Khan, A A;Gunn, H J;Day, M J;Tayebi, M;Ryan, S D;Kuntz, C A;Saad, E S;Richardson, S J;Danks, Janine A
Affiliation: School of Health and Biomedical Sciences, RMIT University, Melbourne, Australia
School of Veterinary Sciences, University of Bristol, Langford, Somerset, UK
Department of Pathology, Faculty of Veterinary and Agricultural Sciences, University of Melbourne, Werribee, Australia
Translational Research and Animal Clinical Trial Study Group (TRACTS), Faculty of Veterinary and Agricultural Sciences, University of Melbourne, Werribee, Australia
Southpaws Veterinary Hospital, Moorabbin, Australia
Department of Medicine, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australia
Issue Date: Nov-2017 2017-10-03
Publication information: Journal of comparative pathology 2017; 157(4): 256-265
Abstract: Osteosarcoma (OS) originates from bone-forming mesenchymal cells and represents one of the primary bone tumours. It is the most common primary bone tumour in dogs and man. The characterization of an appropriate natural disease animal model to study human OS is essential to elucidate the pathogenesis of the disease. This study aimed to validate canine OS as a model for the human disease by evaluating immunohistochemically the expression of markers known to be important in human OS. The immunohistochemical panel included vimentin, alkaline phosphatase (ALP), desmin, S100, neuron-specific enolase (NSE), runt-related transcription factor 2 (Runx2) and bone morphogenetic protein 4 (BMP4). Immunohistochemistry was conducted on formalin-fixed, paraffin wax-embedded tissue sections from 59 dogs with confirmed primary OS. Vimentin, ALP, Runx2 and BMP4 were highly expressed by all tumours, while desmin, S100 and NSE were expressed variably. The findings were similar to those described previously for human OS and suggest that canine OS may represent a useful model for the study of the human disease.
DOI: 10.1016/j.jcpa.2017.07.005
Journal: Journal of comparative pathology
PubMed URL: 29169619
Type: Journal Article
Subjects: dog
Appears in Collections:Journal articles

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