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Title: White Matter Microstructural Organization Is Higher with Age in Adult Superior Cerebellar Peduncles.
Austin Authors: Kanaan, Richard A A ;Allin, Matthew;Picchioni, Marco M;Shergill, Sukhwinder S;McGuire, Philip K
Affiliation: Department of Psychiatry, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australia
Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College LondonLondon, UK
St Andrew's Department, King's College LondonNorthampton, UK
Issue Date: 14-Apr-2016
Date: 2016
Publication information: Frontiers in aging neuroscience 2016; 8: 71
Abstract: Using diffusion tensor imaging, we conducted an exploratory investigation of the relationship between white matter tract microstructure and age in 200 healthy adult subjects using tract-based spatial statistics (TBSS). Though most tracts showed the slight decline in microstructural organization with age widely noted, in both superior cerebellar peduncles (SCP) it correlated positively with age, a result not previously reported. We confirmed this by using an alternative method, and by repeating our TBSS analysis in an additional sample of 133 healthy adults. In exploring this surprising result we considered the possibility that this might arise from the continual cognitive and motor refinement that is enacted in the cerebellum: we found that tract microstructure in both SCPs was also strongly correlated with IQ, again in contrast with all other tracts, and its relationship with age mediated by IQ, as a training model would predict.
DOI: 10.3389/fnagi.2016.00071
ORCID: 0000-0003-0992-1917
Journal: Frontiers in aging neuroscience
PubMed URL: 27148043
ISSN: 1663-4365
Type: Journal Article
Subjects: aging
diffusion tensor imaging
fractional anisotropy
Appears in Collections:Journal articles

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