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Title: Evaluation of Cholinergic Deficiency in Preclinical Alzheimer's Disease Using Pupillometry.
Austin Authors: Frost, Shaun;Robinson, Liam;Rowe, Christopher C ;Ames, David;Masters, Colin L ;Taddei, Kevin;Rainey-Smith, Stephanie R;Martins, Ralph N;Kanagasingam, Yogesan
Affiliation: School of Psychiatry and Clinical Neurosciences, University of Western Australia, Australia, Crawley, WA, Australia
Department of Psychiatry, University of Melbourne, Melbourne, Victoria, Australia
The Mental Health Research Institute (MHRI), University of Melbourne, Melbourne, Victoria, Australia
School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia
Sir James McCusker Alzheimer's Disease Research Unit, Hollywood Private Hospital, Perth, WA, Australia
School of Biomedical Sciences, Macquarie University, North Ryde, NSW, Australia
National Ageing Research Institute, Melbourne, Victoria, Australia
Australian e-Health Research Centre, Perth, WA, Australia
Department of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, Victoria, Australia
Commonwealth Scientific and Industrial Research Organisation (CSIRO), Perth, WA, Australia
Issue Date: 2017 2017-08-16
Publication information: Journal of ophthalmology 2017; 2017: 7935406
Abstract: Cortical cholinergic deficiency is prominent in Alzheimer's disease (AD), and published findings of diminished pupil flash response in AD suggest that this deficiency may extend to the visual cortical areas and anterior eye. Pupillometry is a low-cost, noninvasive technique that may be useful for monitoring cholinergic deficits which generally lead to memory and cognitive disorders. The aim of the study was to evaluate pupillometry for early detection of AD by comparing the pupil flash response (PFR) in AD (N = 14) and cognitively normal healthy control (HC, N = 115) participants, with the HC group stratified according to high (N = 38) and low (N = 77) neocortical amyloid burden (NAB). Constriction phase PFR parameters were significantly reduced in AD compared to HC (maximum acceleration p < 0.05, maximum velocity p < 0.0005, average velocity p < 0.005, and constriction amplitude p < 0.00005). The high-NAB HC subgroup had reduced PFR response cross-sectionally, and also a greater decline longitudinally, compared to the low-NAB subgroup, suggesting changes to pupil response in preclinical AD. The results suggest that PFR changes may occur in the preclinical phase of AD. Hence, pupillometry has a potential as an adjunct for noninvasive, cost-effective screening for preclinical AD.
DOI: 10.1155/2017/7935406
ORCID: 0000-0002-1681-8224
Journal: Journal of ophthalmology
PubMed URL: 28894607
ISSN: 2090-004X
Type: Journal Article
Appears in Collections:Journal articles

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