Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/18440
Title: Cerebral quantitative susceptibility mapping predicts amyloid-β-related cognitive decline
Austin Authors: Ayton, Scott;Fazlollahi, Amir;Bourgeat, Pierrick;Raniga, Parnesh;Ng, Amanda;Lim, Yen Ying;Diouf, Ibrahima;Farquharson, Shawna ;Fripp, Jurgen;Ames, David;Doecke, James;Desmond, Patricia;Ordidge, Roger;Masters, Colin L ;Rowe, Christopher C ;Maruff, Paul;Villemagne, Victor L ;Salvado, Olivier;Bush, Ashley I
Affiliation: National Ageing Research Institute, Parkville, Victoria, Australia
Department of Anatomy and Neuroscience, The University of Melbourne, Parkville, Australia
Department of Medicine and Radiology, Royal Melbourne Hospital, University of Melbourne, Parkville, Australia
Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Australia
CSIRO Health and Biosecurity, Australian E-Health Research Centre, Brisbane, Australia
University of Melbourne Academic Unit for the Psychiatry of Old Age, Parkville, Australia
Cooperative Research Centre for Mental Health, Parkville, Australia
Cogstate Ltd, Melbourne, Australia
Austin Health, Heidelberg, Victoria, Australia
Issue Date: 1-Aug-2017
Publication information: Brain 2017; 140(8): 2112-2119
Abstract: See Derry and Kent (doi:10.1093/awx167) for a scientific commentary on this article.The large variance in cognitive deterioration in subjects who test positive for amyloid-β by positron emission tomography indicates that convergent pathologies, such as iron accumulation, might combine with amyloid-β to accelerate Alzheimer's disease progression. Here, we applied quantitative susceptibility mapping, a relatively new magnetic resonance imaging method sensitive to tissue iron, to assess the relationship between iron, amyloid-β load, and cognitive decline in 117 subjects who underwent baseline magnetic resonance imaging and amyloid-β positron emission tomography from the Australian Imaging, Biomarkers and Lifestyle study (AIBL). Cognitive function data were collected every 18 months for up to 6 years from 100 volunteers who were either cognitively normal (n = 64) or diagnosed with mild cognitive impairment (n = 17) or Alzheimer's disease (n = 19). Among participants with amyloid pathology (n = 45), higher hippocampal quantitative susceptibility mapping levels predicted accelerated deterioration in composite cognition tests for episodic memory [β(standard error) = -0.169 (0.034), P = 9.2 × 10-7], executive function [β(standard error) = -0.139 (0.048), P = 0.004), and attention [β(standard error) = -0.074 (0.029), P = 0.012]. Deteriorating performance in a composite of language tests was predicted by higher quantitative susceptibility mapping levels in temporal lobe [β(standard error) = -0.104 (0.05), P = 0.036] and frontal lobe [β(standard error) = -0.154 (0.055), P = 0.006]. These findings indicate that brain iron might combine with amyloid-β to accelerate clinical progression and that quantitative susceptibility mapping could be used in combination with amyloid-β positron emission tomography to stratify individuals at risk of decline.
URI: http://ahro.austin.org.au/austinjspui/handle/1/18440
DOI: 10.1093/brain/awx137
ORCID: 0000-0003-3910-2453
PubMed URL: 28899019
Type: Journal Article
Subjects: Alzheimer’s
MRI
Quantitative Susceptibility Mapping
cognitive decline
iron
Appears in Collections:Journal articles

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