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Title: Standardization of amyloid quantitation with florbetapir standardized uptake value ratios to the Centiloid scale.
Austin Authors: Navitsky, Michael;Joshi, Abhinay D;Kennedy, Ian;Klunk, William E;Rowe, Christopher C ;Wong, Dean F;Pontecorvo, Michael J;Mintun, Mark A;Devous, Michael D
Affiliation: Departments of Neurology and Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Radiology, Psychiatry, Neuroscience, Neurology, Environmental Health Sciences, and Carey Business School, Johns Hopkins University, Section of High Resolution Brain PET Imaging, Division of Nuclear Medicine, Baltimore, MD, USA
Avid Radiopharmaceuticals, Philadelphia, PA, USA
Department of Nuclear Medicine & Centre for PET, Austin Health, Heidelberg, Victoria, Australia
Department of Medicine, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australia
Issue Date: 2018 2018-07-10
Publication information: Alzheimer's & dementia 2018; 14(12): 1565-1571
Abstract: Klunk et al. recently proposed a means of standardizing quantitation of amyloid burden from positron emission tomography scans to a common Centiloid scale, and we have applied that method to florbetapir. Florbetapir and Pittsburgh compound B scans were acquired for 46 mixed clinical presentation subjects within 18 ± 20 days. Florbetapir and Pittsburgh compound B cortical standardized uptake value ratio (SUVr) values were well correlated for both standard Centiloid (R2 = 0.894) and Avid (R2 = 0.901) volume of interests (VOIs). The methods of Klunk et al. were applied to establish a conversion first from florbetapir SUVr values obtained using standard Centiloid VOIs to Centiloids and then from Avid VOIs (Joshi et al.) to Centiloids. The equation for conversion of florbetapir SUVr from Avid VOIs to the Centiloid scale was as follows: Florbetapir Centiloids = 183 × SUVrAvid - 177. The threshold that discriminated neuropathologically verified none or sparse versus moderate to frequent plaques in autopsy-confirmed data is 24.1 Centiloids. These findings may allow improved tracer-independent amyloid quantitation.
DOI: 10.1016/j.jalz.2018.06.1353
ORCID: 0000-0003-3910-2453
PubMed URL: 30006100
Type: Journal Article
Subjects: Amyloid imaging
Pittsburgh compound B
Appears in Collections:Journal articles

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