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Title: Late presentation of generalised bullous pemphigoid-like reaction in a patient treated with pembrolizumab for metastatic melanoma.
Austin Authors: Parakh, Sagun ;Nguyen, Rebecca;Opie, Jacinta M;Andrews, Miles C
Affiliation: Dermatology Unit, Austin Health, Heidelberg, Victoria, Australia
Medical Oncology Unit, Austin Health, Heidelberg, Victoria, Australia
Olivia Newton-John Cancer Research Institute, Heidelberg, Victoria, Australia
La Trobe University School of Cancer Medicine, Melbourne, Victoria, Australia
Issue Date: Aug-2017 2016-05-11
Publication information: The Australasian journal of dermatology 2017; 58(3): e109-e112
Abstract: Dermatological toxicity is one of the most commonly reported immune-related adverse events in patients receiving checkpoint inhibitor immunotherapy. We report the gradual development of a widespread bullous pemphigoid-like reaction in a metastatic melanoma patient 8 months after commencing treatment with the programmed-death-1 (PD-1) inhibitor pembrolizumab, requiring prolonged corticosteroid therapy. This case highlights the potential for insidious and late development of severe cutaneous toxicity following PD-1 inhibitor therapy and suggests that even prolonged immunosuppression may not necessarily compromise the efficacy of PD-1 inhibition in advanced melanoma.
DOI: 10.1111/ajd.12488
PubMed URL: 27170423
Type: Journal Article
Subjects: bullous pemphigoid
programmed death-1 inhibition
Appears in Collections:Journal articles

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