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Title: Fertility in premenopausal women post autologous stem cell transplant with BEAM conditioning.
Austin Authors: Lasica, Masa;Taylor, Emma;Bhattacharyya, Puja;Bennett, Ashwini ;Cooke, Rachel E;Stern, Catharyn;Agresta, Franca;Ayton, Rosemary;Grigg, Andrew
Affiliation: Department of Clinical Haematology, Austin Health, Heidelberg, Victoria, Australia
Department of Clinical Haematology, Princess Alexandra Hospital, Brisbane, QLD, Australia
Department of Clinical Haematology, Westmead Hospital, Sydney, NSW, Australia
Department of Clinical Haematology, Royal Melbourne Hospital, Melbourne, Victoria, Australia
Royal Women's Hospital, Melbourne, Victoria, Australia
Issue Date: Oct-2016 2016-02-23
Publication information: European journal of haematology 2016; 97(4): 348-352
Abstract: There is currently minimal data on fertility outcomes in premenopausal women undergoing autologous stem cell transplant (ASCT) with carmustine, etoposide, cytarabine and melphalan (BEAM) conditioning. A retrospective analysis of fertility outcomes in premenopausal females aged between 18 and 40 yr who underwent BEAM/ASCT for lymphoma between 1995 and 2011 was performed at four transplant centres. Of 41 premenopausal women who underwent BEAM conditioning, 25 met the inclusion criteria with the main exclusion criterion being inadequate documentation. Eighteen had Hodgkin lymphoma, and seven had non-Hodgkin lymphoma. Median number of chemotherapy regimens pretransplant was 2 (1-3). Seventeen women (68%) with a median age at transplant of 25 yr (range 17-33) recovered their menses. The comparative group without recovery was older with a median age of 34 yr (range 20-40) (P = 0.007). Ten patients, with a median age at transplant of 22 yr (range 17-30), had 15 naturally conceived pregnancies. Chemotherapy regimens and lymphoma type did not obviously influence the incidence of menses recovery or conception. The incidence of recovery of menses and fertility in premenopausal women undergoing BEAM/ASCT for lymphoma is substantial. Younger age at transplant correlates with superior fertility outcomes.
DOI: 10.1111/ejh.12737
Journal: European journal of haematology
PubMed URL: 26773518
Type: Journal Article
Subjects: BEAM
autologous stem cell transplant
Appears in Collections:Journal articles

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