Analysis of shared heritability in common disorders of the brain.

2018-06-22

Anttila, Verneri

Bulik-Sullivan, Brendan

Finucane, Hilary K

Walters, Raymond K

Bras, Jose

Duncan, Laramie

Escott-Price, Valentina

Falcone, Guido J

Gormley, Padhraig

Malik, Rainer

Patsopoulos, Nikolaos A

Metspalu, Andres

Chen, Wei-Min

Waddington, John

Walters, James

Weiser, Mark

Andlauer, Till F M

Cheng, Wei

Sonnen, Joshua A

Cormand, Bru

Schreiber, Stefan

Poon, Wayne W

Berr, Claudine

Cloninger, Robert

Curtis, David

Gejman, Pablo V

Henskens, Frans

Mattingsdal, Morten

Hannequin, Didier

Forstner, Andreas J

Kubisch, Christian

Oh, Sang-Yun

Macaya, Alfons

De Rubeis, Silvia

Scott, Rodney

Webb, Bradley

Parr, Jeremy

Ramos-Quiroga, Josep Antoni

Breen, Gerome

Churchhouse, Claire

Stern, Robert A

Bulik, Cynthia M

Streit, Fabian

Konkashbaev, Anuar

Daly, Mark

Turecki, Gustavo

Dichgans, Martin

Mitchell, Braxton

Faraone, Stephen V

Ferrari, Michel D

Regan, Regina

Guerreiro, Rita

Sánchez-Mora, Cristina

Holmans, Peter

Lanzagorta, Nuria

Kendler, Kenneth S

Gibbs, Raphael

Letenneur, Luc

Koeleman, Bobby

Mathews, Carol A

Price, Alkes

Van Deerlin, Vivianna M

Scharf, Jeremiah

Rothwell, Peter

Hakonarson, Hakon

Valencia-Duarte, Ana

Sklar, Pamela

Williams, Julie

Goate, Alison M

Huyser, Chaim

Baune, Bernhard T

Belin, Andrea C

Wood, Nicholas W

Cotsapas, Chris

Palotie, Aarno

Smoller, Jordan W

Leboyer, Marion

Sullivan, Patrick

Rosand, Jonathan

Reichenberg, Abraham

Corvin, Aiden

Illmann, Cornelia

Sharma, Pankaj

Air, Tracy

Van Eldik, Linda J

Striano, Pasquale

Neale, Benjamin M

Bramon, Elvira

Schott, Jonathan M

van den Maagdenberg, Arn M J M

Anney, Richard

Elia, Josephine

Grigoroiu-Serbanescu, Maria

Jenike, Michael

Sandin, Sven

Edenberg, Howard J

Battaglia, Agatino

Murray, Robin

Buccola, Nancy

Harold, Denise

Sudlow, Cathie

Ribasés, Marta

Russo, Giancarlo

Rubinsztein, David C

Bayer, Anthony

Kuperman, Samuel

Tsolaki, Magda

Lee, Phil H

Vorstman, Jacob

Attia, John

Wedenoja, Juho

Proitsi, Petra

Fox, Nick C

Hampel, Harald

Owen, Michael J

Mead, Simon

Ripke, Stephan

Leventhal, Bennett

Vicente, Astrid

Passmore, Peter

Demirci, F Yesim

Morgan, Kevin

Nöthen, Markus M

Sinnamon, Grant

Wassink, Thomas

Rossor, Martin

Lupton, Michelle K

Zwart, John-Anker

Hoffmann, Per

Leverenz, James B

Kornhuber, Johannes

Greenberg, Erica

Lawlor, Brian

Casas, Miguel

McQuillin, Andrew

Markus, Hugh

Wray, Naomi R

Al-Chalabi, Ammar

Wijsman, Ellen

Bis, Joshua C

Ruiz, Agustin

Schosser, Alexandra

Buring, Julie E

Boada, Mercè

Seshadri, Sudha

Beiser, Alexa

Boomsma, Dorret

Rice, Kenneth

Hervas, Amaia

Huang, Hailiang

van der Lee, Sven J

De Jager, Philip L

Vepsäläinen, Salli

Cahn, Wiepke

Lochner, Christine

Kourkoulis, Christina

Geschwind, Daniel H

Riemenschneider, Matthias

Riedel-Heller, Steffi

Rotter, Jerome I

Ransmayr, Gerhard

Hyman, Bradley T

Head, Elizabeth

Cruchaga, Carlos

Cairns, Murray

Arranz, Maria Jesús

Lyon, Gholson J

Eriksson, Nicholas

Julià, Antonio

Alegret, Montserrat

Winsvold, Bendik

Pera, Joana

Palta, Priit

Farh, Kai-How

Cuenca-Leon, Ester

Chong, Siow A

MacIntyre, Donald J

Furlotte, Nicholas

Ophoff, Roel

Kurth, Tobias

Olesen, Jes

Haavik, Jan

Cook, Edwin

Chasman, Daniel I

Nyholt, Dale R

Avbersek, Andreja

Cohen, David

Baum, Larry

Ran, Caroline

Porteous, David

Heinzen, Erin L

Berkovic, Samuel F

Bradfield, Jonathan

Turley, Patrick

Buono, Russell

Catarino, Claudia B

Ligthart, Lannie

Crespo-Facorro, Benedicto

Zayats, Tetyana

Cossette, Patrick

De Jonghe, Peter

Depondt, Chantal

Macciardi, Fabio

Homuth, Georg

Dlugos, Dennis

Ferraro, Thomas N

Raffeld, Miriam

French, Jacqueline

Pozo-Rosich, Patricia

Hjalgrim, Helle

Jamnadas-Khoda, Jennifer

Santangelo, Susan

Grenier-Boley, Benjamin

Johansson, Stefan

Madruga-Garrido, Marcos

Kälviäinen, Reetta

Rivera, Margarita

Kunz, Wolfram S

Lerche, Holger

Levitt, Pat

Leu, Costin

Lindhout, Dick

Lo, Warren

Silliman, Scott

Lowenstein, Daniel

Delorme, Richard

Ryten, Mina

McCormack, Mark

Møller, Rikke S

Heutink, Peter

Quinn, Joseph F

Williams, Nigel

Molloy, Anne

Chouraki, Vincent

Ng, Ping-Wing

Oliver, Karen L

Privitera, Michael

Radtke, Rodney

Salomaa, Veikko

Ruppert, Ann-Kathrin

Rogé, Bernadette

Crowley, James

Amouyel, Philippe

Betancur, Catalina

Sander, Thomas

Schachter, Steven

Dempfle, Astrid

Schankin, Christoph

Scheffer, Ingrid E

Schoch, Susanne

Malaty, Irene A

Kamatani, Yoichiro

Kaye, Jeffrey A

Sisodiya, Sanjay M

Boraska Perica, Vesna

Magalhaes, Tiago

Grove, Jakob

Thornton, Laura M

Huckins, Laura M

William Rayner, N

Lewis, Cathryn M

Surges, Rainer

Maras, Athanasios

Espeseth, Thomas

Gratacos, Monica

Rybakowski, Filip

Gordon, Scott D

Keski-Rahkonen, Anna

Raevuori, Anu

Smith, Philip

Kukull, Walter A

Hudson, James I

Boland, Anne

Reichborn-Kjennerud, Ted

Davidson, Michael

McGrath, Lauren

Monteleone, Palmiero

Karwautz, Andreas

Rothenberger, Aribert

Mannik, Katrin

Baker, Jessica H

O'Toole, Julie K

Middeldorp, Christel M

Borck, Guntram

Arking, Dan

DeLisi, Lynn

Trace, Sara E

Miguel, Eurípedes C

Davis, Oliver S P

Helder, Sietske G

Ehrlich, Stefan

Deleuze, Jean-François

Herpertz-Dahlmann, Beate

Huentelman, Matthew J

Danner, Unna N

Hickie, Ian

Mitchell, James

van Elburg, Annemarie A

Clementi, Maurizio

Alfredsson, Lars

Schulze, Thomas G

Forzan, Monica

Adams, Hieab H H

Docampo, Elisa

Lissowska, Jolanta

Hauser, Joanna

Tortorella, Alfonso

Battey, Thomas

Maj, Mario

Pergadia, Michele

Schürks, Markus

Pato, Carlos

Duron, Emmanuelle

Gonidakis, Fragiskos

Thompson, Robert C

Tziouvas, Konstantinos

Papezova, Hana

Yilmaz, Zeynep

Dinan, Timothy

Lehtimäki, Terho

Wagner, Gudrun

Kuntsi, Jonna

Mehta, Divya

Mir, Pablo

Oades, Robert D

Banaschewski, Tobias

Franke, Barbara

Buitelaar, Jan K

Rabionet, Raquel

Donohoe, Gary

Arias Vasquez, Alejandro

Doyle, Alysa E

Thomas, G Neil

Reif, Andreas

Lesch, Klaus-Peter

Cohen-Woods, Sarah

Huang, Jie

Freitag, Christine

Hrafnsdottir, Maria

Kamboh, M Ilyas

Drapeau, Elodie

Rivero, Olga

Palmason, Haukur

Strohmaier, Jana

Romanos, Marcel

Langley, Kate

Rietschel, Marcella

Nestadt, Gerald

Visscher, Frank

Smit, Johannes H

Witt, Stephanie H

Duan, Jubao

Dalsgaard, Soeren

Børglum, Anders D

Waldman, Irwin

Hottenga, Jouke-Jan

Wilmot, Beth

Martin, Nicholas G

Larson, Eric B

Levey, Allan I

Molly, Nikolas

Bau, Claiton H D

Maestrini, Elena

Hulette, Christine M

Crosbie, Jennifer

Whelan, Christopher D

Schachar, Russell

Loo, Sandra K

McGough, James J

Grevet, Eugenio H

Medland, Sarah E

Nicolini, Humberto

Marson, Anthony

Hanna, Gregory L

Penninx, Brenda

Robinson, Elise

Jansen, Rick

Weiss, Lauren A

Rogaeva, Ekaterina

Bacchelli, Elena

Zara, Federico

Bailey, Anthony

Matthews, Keith

Okun, Michael S

Haan, Lieuwe

Melle, Ingrid

Morris, Derek

Blackwood, Douglas

McIntosh, Andrew

Bolton, Patrick

Bergen, Sarah E

Farrer, Lindsay A

Dick, Danielle M

Schalling, Martin

Jamain, Stéphane

Bal, Vanessa

Mok, Kin Y

Maaser, Anna

Becker, Felicitas

Montgomery, Grant W

Fischer, Sascha B

Reinbold, Céline S

de Geus, Eco

Fullerton, Janice M

Guzman-Parra, José

Mayoral, Fermin

Hougaard, David

Vardarajan, Badri N

Pakstis, Andrew

Schofield, Peter R

Cichon, Sven

Barnes, Lisa L

Mühleisen, Thomas W

Stroink, Hans

Degenhardt, Franziska

Martinez, Maria

Kurki, Mitja I

Hansen, Thomas

Schumacher, Johannes

Bauer, Michael

Loehrer, Elizabeth

Mitchell, Philip B

Ripatti, Samuli

Gershon, Elliot S

Rice, John

Potash, James B

Zandi, Peter P

Craddock, Nick

Karachanak-Yankova, Sena

Lundervold, Astri J

Zimprich, Fritz

Beach, Thomas G

Paschou, Peristera

Ferrier, I Nicol

Wei, Zhi

Alda, Martin

Andreassen, Ole A

Rouleau, Guy A

Dunn, Erin

Saykin, Andrew J

Li, Qingqin S

Nauck, Matthias

Schoevers, Robert A

Beekman, Aartjan Tf

Anjorin, Adebayo

Knowles, James A

Sandor, Cynthia

Cantor, Rita

Viktorin, Alexander

Arnold, Paul

Strober, Michael

Jicha, Gregory A

Steen, Vidar M

Morris, Huw R

Barr, Cathy L

Bedoya-Berrio, Gabriel

Piacentini, John

Bienvenu, O Joseph

Brentani, Helena

Burton, Christie

Artto, Ville

Khrunin, Andrey

Camarena, Beatriz

Cappi, Carolina

Webber, Caleb

Cath, Danielle

Pinto, Dalila

Cavallini, Maria

Reitz, Christiane

Sharma, Manu

Cusi, Daniele

Kauwe, John S K

Boncoraglio, Giorgio

Darrow, Sabrina

Celestino-Soper, Patrícia

Denys, Damiaan

Derks, Eske M

Dietrich, Andrea

Fernandez, Thomas

Figee, Martijn

St George-Hyslop, Peter

Scherer, Stephen W

Muller-Myhsok, Bertram

Klovins, Janis

Freimer, Nelson

Terwindt, Gisela M

Gerber, Gloria

Dawson, Geraldine

Grados, Marco

Pittenger, Christopher

Plessen, Kerstin

Ramensky, Vasily

Ramos, Eliana M

Reus, Victor

Hartmann, Andreas

Lieberman, Andrew P

Pulit, Sara

Stahl, Eli

Richter, Margaret A

Riddle, Mark A

Göbel, Hartmut

Duque, Frederico

Padyukov, Leonid

Robertson, Mary M

Roessner, Veit

Kučinskas, Vaidutis

Rosário, Maria

Samuels, Jack F

Sandor, Paul

Gasser, Thomas

Stein, Dan J

Tsetsos, Fotis

Bevan, Steve

Van Nieuwerburgh, Filip

Green, Andrew

Pankratz, Vernon S

Kaunisto, Mari

Halmi, Katherine A

Weatherall, Sarah

Yu, Dongmei

Wendland, Jens R

Leber, Markus

Wolanczyk, Tomasz

Worbe, Yulia

Zai, Gwyneth

Goes, Fernando S

McLaughlin, Nicole

Hämäläinen, Eija

Klauck, Sabine M

Holliday, Elizabeth

Nestadt, Paul S

Sperling, Michael

Grabe, Hans-Jorgen

Czerski, Piotr M

Depienne, Christel

Lee Chee Keong, Jimmy

Limborska, Svetlana

Loughland, Carmel

Lönnqvist, Jouko

Maher, Brion

Werge, Thomas

Bergen, Andrew W

Hirschtritt, Matthew E

Mattheisen, Manuel

McDonald, Colm

Thijs, Vincent N

Cruceanu, Cristiana

Mane, Shrikant

Schneider, Lon S

Murphy, Kieran C

Nenadic, Igor

van Os, Jim

Pantelis, Christos

Aschauer, Harald

Pato, Michele

Petryshen, Tracey

Kaye, Walter

Quested, Digby

Jones, Ian R

Kaprio, Jaakko

De-Luca, Daniel Moreno-

Roussos, Panos

Freilinger, Tobias

Sanders, Alan R

Hoekstra, Pieter J

Schall, Ulrich

Smith, Amanda G

Schwab, Sibylle G

Sim, Kang

So, Hon-Cheong

Posthuma, Danielle

Szatkiewicz, Jin Peng

Stögmann, Elisabeth

Herms, Stefan

Subramaniam, Mythily

Huang, Alden

Toncheva, Draga

Journal Article

0000-0002-0073-4675

0000-0003-3864-9828

0000-0001-8422-6530

0000-0003-1131-661X

0000-0003-1784-5483

0000-0002-6407-0302

0000-0002-8908-6968

0000-0001-9212-2520

0000-0003-3622-835X

0000-0001-6059-4267

0000-0001-7901-4365

0000-0003-1770-3100

0000-0003-2053-1792

0000-0001-7772-3264

0000-0002-0949-8752

0000-0002-0654-387X

0000-0002-9217-3982

0000-0003-0870-9412

0000-0001-7749-182X

0000-0003-2208-7058

0000-0001-9715-4943

0000-0002-4069-0259

0000-0002-9500-3348

0000-0002-7772-5910

0000-0002-0381-6334

0000-0002-6619-873X

0000-0002-1014-9138

0000-0001-6717-4089

0000-0003-1513-6077

0000-0002-2311-2174

0000-0002-6614-8417

0000-0003-4580-841X

10.1126/science.aap8757

Disorders of the brain can exhibit considerable epidemiological comorbidity and often share symptoms, provoking debate about their etiologic overlap. We quantified the genetic sharing of 25 brain disorders from genome-wide association studies of 265,218 patients and 784,643 control participants and assessed their relationship to 17 phenotypes from 1,191,588 individuals. Psychiatric disorders share common variant risk, whereas neurological disorders appear more distinct from one another and from the psychiatric disorders. We also identified significant sharing between disorders and a number of brain phenotypes, including cognitive measures. Further, we conducted simulations to explore how statistical power, diagnostic misclassification, and phenotypic heterogeneity affect genetic correlations. These results highlight the importance of common genetic variation as a risk factor for brain disorders and the value of heritability-based methods in understanding their etiology.

link

Science (New York, N.Y.) 2018; 360(6395): eaap8757

Science (New York, N.Y.)