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Title: Optimal clinical management of children receiving dietary therapies for epilepsy: Updated recommendations of the International Ketogenic Diet Study Group.
Austin Authors: Kossoff, Eric H;Zupec-Kania, Beth A;Auvin, Stéphane;Ballaban-Gil, Karen R;Christina Bergqvist, A G;Blackford, Robyn;Buchhalter, Jeffrey R;Caraballo, Roberto H;Cross, J Helen;Dahlin, Maria G;Donner, Elizabeth J;Guzel, Orkide;Jehle, Rana S;Klepper, Joerg;Kang, Hoon-Chul;Lambrechts, Danielle A;Liu, Y M Christiana;Nathan, Janak K;Nordli, Douglas R;Pfeifer, Heidi H;Rho, Jong M;Scheffer, Ingrid E ;Sharma, Suvasini;Stafstrom, Carl E;Thiele, Elizabeth A;Turner, Zahava;Vaccarezza, Maria M;van der Louw, Elles J T M;Veggiotti, Pierangelo;Wheless, James W;Wirrell, Elaine C
Affiliation: Departments of Neurology and Pediatrics Johns Hopkins Outpatient Center Baltimore Maryland U.S.A..
Department of Pediatrics Lady Hardinge Medical College New Delhi India
Department of Paediatrics Alberta Children's Hospital Calgary Alberta Canada
The Charlie Foundation Santa Monica California U.S.A
Department of Pediatric Neurology CHU Hôpital Robert Debré Paris France
Department of Neurology and Pediatrics Montefiore Medical Center/Albert Einstein College of Medicine Bronx New York U.S.A
Department of Neurology The Childrens Hospital of Philadelphia Philadelphia Pennsylvania U.S.A
Department of Nutrition Lurie Children's Hospital Chicago Illinois U.S.A
Department of Pediatrics Alberta Children's Hospital Calgary Alberta Canada
Department of Neurology Hospital J P Garrahan, Capital Federal Buenos Aires Argentina
Department of Clinical & Experimental Epilepsy Great Ormond Street Hospital University College London London United Kingdom
Department of Clinical Neuroscience, Women's and Children's Health Karolinska Institute Stockholm Sweden
Division of Neurology The Hospital for Sick Children Toronto Ontario Canada
Department of Pediatric Neurology Izmir Dr. Behcet Uz Children's Hospital Izmir Turkey
Department of Neurology Montefiore Medical Center Bronx New York U.S.A
Department of Pediatrics and Neuropediatrics Children's Hospital Aschaffenburg Aschaffenburg Germany
Department of Pediatrics Pediatric Epilepsy Clinic Severance Children's Hospital Seoul Korea
Department of Neurology Epilepsy Centre Kempenhaeghe Heeze The Netherlands
Department of Neurology The Hospital for Sick Children Toronto Ontario Canada
Department of Child Neurology Shushrusha Hospital Mumbai India
Department of Neurology Children's Hospital of Los Angeles Los Angeles California U.S.A..
Department of Neurology Massachusetts General Hospital Boston Massachusetts U.S.A..
Epilepsy Research Centre, Department of Medicine, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australia
Departments of Pediatrics and Neurology Johns Hopkins Hospital Baltimore Maryland U.S.A
Department of Pediatrics The Johns Hopkins University Baltimore Maryland U.S.A
Department of Neurology Hospital Italiano de Buenos Aires Buenos Aires Argentina
Department of Dietetics Sophia Children's Hospital Erasmus Medical Centre Rotterdam The Netherlands
Infantile Neuropsychiatry Neurological Institute Foundation Casimiro Mondino Pavia Italy
Department of Pediatric Neurology University of Tennessee Memphis Tennessee U.S.A
Department of Neurology, Child and Adolescent Neurology Mayo Clinic Rochester Minnesota U.S.A
Issue Date: Jun-2018 2018-05-21
Publication information: Epilepsia open 2018; 3(2): 175-192
Abstract: Ketogenic dietary therapies (KDTs) are established, effective nonpharmacologic treatments for intractable childhood epilepsy. For many years KDTs were implemented differently throughout the world due to lack of consistent protocols. In 2009, an expert consensus guideline for the management of children on KDT was published, focusing on topics of patient selection, pre-KDT counseling and evaluation, diet choice and attributes, implementation, supplementation, follow-up, side events, and KDT discontinuation. It has been helpful in outlining a state-of-the-art protocol, standardizing KDT for multicenter clinical trials, and identifying areas of controversy and uncertainty for future research. Now one decade later, the organizers and authors of this guideline present a revised version with additional authors, in order to include recent research, especially regarding other dietary treatments, clarifying indications for use, side effects during initiation and ongoing use, value of supplements, and methods of KDT discontinuation. In addition, authors completed a survey of their institution's practices, which was compared to responses from the original consensus survey, to show trends in management over the last 10 years.
DOI: 10.1002/epi4.12225
ORCID: 0000-0003-3874-9749
PubMed URL: 29881797
ISSN: 2470-9239
Type: Journal Article
Subjects: Children
Appears in Collections:Journal articles

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