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Title: Prediction of Outcome in Patients With Acute Ischemic Stroke Based on Initial Severity and Improvement in the First 24 h.
Austin Authors: Wouters, Anke;Nysten, Céline;Thijs, Vincent N ;Lemmens, Robin
Affiliation: Department of Neurosciences, Experimental Neurology, KU Leuven - University of Leuven, Leuven, Belgium
Laboratory of Neurobiology, Center for Brain and Disease Research, VIB, Leuven, Belgium
Department of Neurology, University Hospitals Leuven, Leuven, Belgium
Stroke Division, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Heidelberg, Victoria, Australia
Department of Neurology, Austin Health, Heidelberg, Victoria, Australia
Issue Date: 2018 2018-05-07
Publication information: Frontiers in neurology 2018; 9: 308
Abstract: Stroke severity measured by the baseline National Institutes of Health Stroke Scale (NIHSS) is a strong predictor of stroke outcome. Early change of baseline severity may be a better predictor of outcome. Here, we hypothesized that the change in NIHSS in the first 24 h after stroke improved stroke outcome prediction. Patients from the Leuven Stroke Genetics Study were included when the baseline NIHSS (B-NIHSS) was determined on admission in the hospital and NIHSS after 24 h could be obtained from patient files. The delta NIHSS, relative reduction NIHSS, and major neurological improvement (NIHSS of 0-1 or ≥8-point improvement at 24 h) were calculated. Good functional outcome (GFO) at 90 days was defined as a modified Rankin Scale of 0-2. Independent predictors of outcome were identified by multivariate logistic regression. We performed a secondary analysis after excluding patients presenting with a minor stroke (NIHSS 0-5) since the assessment of change in NIHSS might be more reliable in patients presenting with a moderate to severe deficit. We analyzed the outcome in 369 patients. B-NIHSS was associated with GFO (odds ratio: 0.82; 95% CI 0.77-0.86). In a multivariate model with B-NIHSS and age as predictors, the accuracy [area under the curve (AUC): 0.82] improved by including the delta NIHSS (AUC: 0.86; p < 0.01). In 131 patients with moderate to severe stroke, the predictive multivariate model was more accurate when including the RR NIHSS (AUC: 0.83) to the model which included B-NIHSS, age and ischemic heart disease (AUC: 0.77; p = 0.03). B-NIHSS is a predictor of stroke outcome. In this cohort, the prediction of GFO was improved by adding change in stroke severity after 24 h to the model.
DOI: 10.3389/fneur.2018.00308
ORCID: 0000-0002-6614-8417
PubMed URL: 29867722
ISSN: 1664-2295
Type: Journal Article
Subjects: National Institutes of Health Stroke Scale
baseline National Institutes of Health Stroke Scale
delta National Institutes of Health Stroke Scale
Ischaemic Stroke
major neurological improvement
modified Rankin scale
relative reduction National Institutes of Health Stroke Scale
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