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Title: White matter deficits in schizophrenia are global and don't progress with age.
Austin Authors: Kanaan, Richard A A ;Picchioni, Marco M;McDonald, Colm;Shergill, Sukhwinder S;McGuire, Philip K
Affiliation: Department of Psychiatry, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australia
Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK
St Andrew's Academic Department and King's College London, Northampton, UK
National University of Ireland (NUI), Galway, Ireland
Issue Date: Oct-2017 2017-04-06
Publication information: The Australian and New Zealand Journal of Psychiatry 2017; 51(10): 1020-1031
Abstract: Diffusion tensor imaging has revealed differences in all examined white matter tracts in schizophrenia, with a range of explanations for why this may be. The distribution and timing of differences may help explain their origin; however, results are usually dependent on the analytical method. We therefore sought to examine the extent of differences and their relationship with age using two different methods. A combined voxel-based whole-brain study and a tract-based spatial-statistics study of 104 patients with schizophrenia and 200 matched healthy controls, aged between 17 and 63 years. Fractional anisotropy was reduced throughout the brain in both analyses. The relationship of fractional anisotropy with age differed between patients and controls, with controls showing the gentle fractional anisotropy decline widely noted but patients showing an essentially flat relationship: younger patients had lower fractional anisotropy than controls, but the difference disappeared with age. Mean diffusivity was widely increased in patients. Reduction in fractional anisotropy and increase in mean diffusivity would be consistent with global disruption in myelination; the relationship with age would suggest this is present already at the onset of their illness, but does not progress.
DOI: 10.1177/0004867417700729
ORCID: 0000-0003-0992-1917
Journal: The Australian and New Zealand Journal of Psychiatry
PubMed URL: 28382844
Type: Journal Article
Subjects: DTI
Diffusion tensor imaging
antipsychotic medication
illness duration
Appears in Collections:Journal articles

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