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Title: Benefits of home-based multidisciplinary exercise and supportive care in inoperable non-small cell lung cancer - protocol for a phase II randomised controlled trial.
Austin Authors: Edbrooke, Lara;Aranda, Sanchia;Granger, Catherine L ;McDonald, Christine F ;Krishnasamy, Mei;Mileshkin, Linda;Irving, Louis;Braat, Sabine;Clark, Ross A;Gordon, Ian;Denehy, Linda
Affiliation: Department of Physiotherapy, The University of Melbourne, Parkville, Victoria, Australia
Cancer Council Australia, Sydney, NSW, Australia
Institute for Breathing and Sleep, Austin Health, Heidelberg, Victoria, Australia
Department of Respiratory and Sleep Medicine, Austin Health, Heidelberg, Victoria, Australia
Department of Nursing, The University of Melbourne, Parkville, Victoria, Australia
The University of Melbourne Centre for Cancer Research, Parkville, Victoria, Australia
The Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
Department of Respiratory and Sleep Medicine, Melbourne Health, Parkville, Victoria, Australia
Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, Australia
University of the Sunshine Coast, Sunshine Coast, QLD, Australia
Statistical Consulting Centre, The University of Melbourne, Parkville, Victoria, Australia
Issue Date: 29-Sep-2017 2017-09-29
Publication information: BMC cancer 2017; 17(1): 663
Abstract: Lung cancer is one of the most commonly diagnosed cancers, and is a leading cause of cancer mortality world-wide. Due to lack of early specific symptoms, the majority of patients present with advanced, inoperable disease and five-year relative survival across all stages of non-small cell lung cancer (NSCLC) is 14%. People with lung cancer also report higher levels of symptom distress than those with other forms of cancer. Several benefits for survival and patient reported outcomes are reported from physical activity and exercise in other tumour groups. We report the protocol for a study investigating the benefits of exercise, behaviour change and symptom self-management for patients with recently diagnosed, inoperable, NSCLC. This multi-site, parallel-group, assessor-blinded randomised controlled trial, powered for superiority, aims to assess functional and patient-reported outcomes of a multi-disciplinary, home-based exercise and supportive care program for people commencing treatment. Ninety-two participants are being recruited from three tertiary-care hospitals in Melbourne, Australia. Following baseline testing, participants are randomised using concealed allocation, to receive either: a) 8 weeks of home-based exercise (comprising an individualised endurance and resistance exercise program and behaviour change coaching) and nurse-delivered symptom self-management intervention or b) usual care. The primary outcome is the between-group difference in the change in functional exercise capacity (six-minute walk distance) from baseline to post-program assessment. Secondary outcomes include: objective and self-reported physical activity levels, physical activity self-efficacy, behavioural regulation of motivation to exercise and resilience, muscle strength (quadriceps and grip), health-related quality of life, anxiety and depression and symptom interference. There is a lack of evidence regarding the benefit of exercise intervention for people with NSCLC, particularly in those with inoperable disease receiving treatment. This trial will contribute to evidence currently being generated in national and international trials by implementing and evaluating a home-based program including three components not yet combined in previous research, for people with inoperable NSCLC receiving active treatment and involving longer-term follow-up of outcomes. This trial is ongoing and currently recruiting. This trial was prospectively registered on the Australian New Zealand Clinical Trials Registry ( ACTRN12614001268639 : (4/12/14).
DOI: 10.1186/s12885-017-3651-4
ORCID: 0000-0002-4149-5578
PubMed URL: 28962608
Type: Journal Article
Subjects: Home-based exercise
Non-small cell lung cancer
Physical function
Supportive care
Symptom control
Appears in Collections:Journal articles

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