De novo activating epidermal growth factor mutations (EGFR) in small-cell lung cancer.

2017-09

Thai, Alesha

Chia, Puey L

Russell, Prudence A

Do, Hongdo

Dobrovic, Alexander

Mitchell, Paul L R

John, Thomas

EGFR mutation

de novo

cell free DNA

circulating DNA

small-cell lung cancer

Journal Article

0000-0001-8966-7677

0000-0003-3414-112X

10.1111/imj.13531

In Australia, mutations in epidermal growth factor mutations (EGFR) occur in 15% of patients diagnosed with non-small-cell lung cancer and are found with higher frequency in female, non-smokers of Asian ethnicity. Activating mutations in the EGFR gene are rarely described in SCLC. We present two cases of de novo EGFR mutations in patients with SCLC detected in tissue and in plasma cell free DNA, both of whom were of Asian ethnicity and never-smokers. These two cases add to the growing body of evidence suggesting that screening for EGFR mutations in SCLC should be considered in patients with specific clinical features.

link

Internal Medicine Journal 2017; 47(9): 1071-1074

Internal Medicine Journal