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Title: De novo activating epidermal growth factor mutations (EGFR) in small-cell lung cancer.
Austin Authors: Thai, Alesha;Chia, Puey L;Russell, Prudence A;Do, Hongdo;Dobrovic, Alexander ;Mitchell, Paul L R ;John, Thomas 
Affiliation: Department of Medical Oncology, Austin Health, Heidelberg, Victoria, Australia
Department of Anatomical Pathology, St Vincent's Hospital, University of Melbourne, Melbourne, Victoria, Australia
Olivia Newton-John Cancer Research Institute, Heidelberg, Victoria, Australia
Issue Date: Sep-2017
Publication information: Internal Medicine Journal 2017; 47(9): 1071-1074
Abstract: In Australia, mutations in epidermal growth factor mutations (EGFR) occur in 15% of patients diagnosed with non-small-cell lung cancer and are found with higher frequency in female, non-smokers of Asian ethnicity. Activating mutations in the EGFR gene are rarely described in SCLC. We present two cases of de novo EGFR mutations in patients with SCLC detected in tissue and in plasma cell free DNA, both of whom were of Asian ethnicity and never-smokers. These two cases add to the growing body of evidence suggesting that screening for EGFR mutations in SCLC should be considered in patients with specific clinical features.
DOI: 10.1111/imj.13531
ORCID: 0000-0001-8966-7677
PubMed URL: 28891180
Type: Journal Article
Subjects: EGFR mutation
de novo
cell free DNA
circulating DNA
small-cell lung cancer
Appears in Collections:Journal articles

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