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Title: Mechanical loading of the femoral neck in human locomotion.
Austin Authors: Kersh, Mariana E;Martelli, Saulo;Zebaze, Roger M D;Seeman, Ego ;Pandy, Marcus G
Affiliation: Department of Mechanical Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois
Medical Device Research Institute Flinders University, Adelaide, South Australia
Medicine (University of Melbourne)
Mary Mackillop Institute for Health Research, Australian Catholic University, Victoria, Australia
Department of Mechanical Engineering University of Melbourne, Parkville, Victoria, Australia
Issue Date: 2018
Date: 2018-06-19
Publication information: Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research 2018; online first: 19 Jun
Abstract: Advancing age and reduced loading are associated with a reduction in bone formation. Conversely, loading increases periosteal apposition and may reduce remodeling imbalance and slow age-related bone loss, an important outcome for the proximal femur which is a common site of fracture. The ability to take advantage of bone's adaptive response to increase bone strength has been hampered by a lack of knowledge of which exercises and specific leg muscles load the superior femoral neck: a common region of microcrack initiation and progression following a sideways fall. We used an in vivo method of quantifying focal strains within the femoral neck in postmenopausal women during walking, stair ambulation, and jumping. Relative to walking, stair ambulation and jumping induced significantly higher strains in the anterior and superior aspects of the femoral neck, common regions of microcrack initiation and progression following a fall. The gluteus maximus, a hip extensor muscle, induced strains in the femoral neck during stair ambulation and jumping, in contrast to walking which induced strains via the iliopsoas, a hip flexor. The ground reaction force was closely associated with the level of strain during each task, providing a surrogate indicator of the potential for a given exercise to load the femoral neck. The gluteal muscles combined with an increased ground reaction force relative to walking induce high focal strains within the anterosuperior region of the femoral neck and therefore provide a target for exercise regimens designed to slow bone loss and maintain or improve microstructural strength. Model files used for calculating femoral neck strains are available at This article is protected by copyright. All rights reserved.
DOI: 10.1002/jbmr.3529
ORCID: 0000-0002-9692-048X
Journal: Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
PubMed URL: 29920773
Type: Journal Article
Subjects: bone
proximal femur
Appears in Collections:Journal articles

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