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Title: Amygdala enlargement: Temporal lobe epilepsy subtype or nonspecific finding?
Austin Authors: Reyes, Anny;Thesen, Thomas;Kuzniecky, Ruben;Devinsky, Orrin;McDonald, Carrie R;Jackson, Graeme D ;Vaughan, David N;Blackmon, Karen
Affiliation: New York University School of Medicine, Department of Neurology, Epilepsy Division, New York, NY, United States
New York University School of Medicine, Department of Radiology, New York, NY, United States
University of California San Diego, Center for Multimodal Imaging and Genetics (CMIG), San Diego, CA, United States
The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Heidelberg, Victoria, Australia
Department of Neurology, Austin Health, Heidelberg, Victoria, Australia
St. Georges University School of Medicine, Department of Behavioral Sciences, St. Georges, Grenada
Issue Date: May-2017 2017-03-02
Publication information: Epilepsy research 2017; 132: 34-40
Abstract: Amygdala enlargement (AE) is observed in patients with temporal lobe epilepsy (TLE), which has led to the suggestion that it represents a distinct TLE subtype; however, it is unclear whether AE is found at similar rates in other epilepsy syndromes or in healthy controls, which would limit its value as a marker for focal epileptogenicity. We compared rates of AE, defined quantitatively from high-resolution T1-weighted MRI, in a large multi-site sample of 136 patients with nonlesional localization related epilepsy (LRE), including TLE and extratemporal (exTLE) focal epilepsy, 34 patients with idiopathic generalized epilepsy (IGE), and 233 healthy controls (HCs). AE was found in all groups including HCs; however, the rate of AE was higher in LRE (18.4%) than in IGE (5.9%) and HCs (6.4%). Patients with unilateral LRE were further evaluated to compare rates of concordant ipsilateral AE in TLE and exTLE, with the hypothesis that rates of ipsilateral AE would be higher in TLE. Although ipsilateral AE was higher in TLE (19.4%) than exTLE (10.5%), this difference was not significant. Furthermore, among the 25 patients with unilateral LRE and AE, 13 (52%) had either bilateral AE or AE contralateral to seizure onset. Results suggest that AE, as defined with MRI volumetry, may represent an associated feature of nonlesional localization related epilepsy with limited seizure onset localization value.
DOI: 10.1016/j.eplepsyres.2017.02.019
ORCID: 0000-0002-6225-7739
PubMed URL: 28284051
Type: Journal Article
Subjects: MRI
Nonlesional epilepsy
Temporal lobe epilepsy
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