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Title: Increased Carbohydrate Intake is Associated with Poorer Performance in Verbal Memory and Attention in an APOE Genotype-Dependent Manner.
Austin Authors: Gardener, Samantha L;Rainey-Smith, Stephanie R;Sohrabi, Hamid R;Weinborn, Michael;Verdile, Giuseppe;Fernando, W M A D Binosha;Lim, Yen Ying;Harrington, Karra;Burnham, Samantha;Taddei, Kevin;Masters, Colin L ;Macaulay, Stuart L;Rowe, Christopher C ;Ames, David;Maruff, Paul;Martins, Ralph N
Affiliation: CogState, Ltd., Melbourne, Victoria, Australia
Centre of Excellence for Alzheimer's disease Research & Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia
Sir James McCusker Alzheimer's Disease Research Unit (Hollywood Private Hospital), Perth, WA, Australia
Department of Biomedical Sciences, Macquarie University, NSW, Australia
School of Psychology, University of Western Australia, Crawley, WA, Australia
School of Biomedical Sciences, Faculty of Health Sciences, Curtin Health Innovation Research Institute, Curtin University of Technology, Bentley, WA, Australia
The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia
Cooperative Research Centre (CRC) for Mental Health, Carlton South, Victoria, Australia
CSIRO Computational Informatics, Preventative Health Flagship, Floreat, WA, Australia
CSIRO Preventative Health Flagship, CMSE Parkville, Victoria, Australia
Department of Molecular Imaging and Therapy, Centre for PET, Austin Health, Heidelberg, Victoria, Australia
National Ageing Research Institute, Royal Melbourne Hospital, Melbourne, Australia
Academic Unit for Psychiatry of Old Age, University of Melbourne, Melbourne, Australia
Issue Date: 2017
Publication information: Journal of Alzheimer's disease : JAD 2017; 58(1): 193-201
Abstract: Evidence suggests that a diet low in carbohydrates can impact on cognitive performance among those with Alzheimer's disease (AD). However, there is a lack of data assessing this relationship among cognitively normal (CN) older adults at increased future risk of developing AD due to carriage of the apolipoprotein E (APOE) ɛ4 allele. We assessed the cross-sectional association between carbohydrate intake, cognitive performance, and cerebral amyloid-β (Aβ) load in CN older adults, genotyped for APOEɛ4 allele carrier status. Greater carbohydrate intake was associated with poorer performance in verbal memory in APOEɛ4 allele non-carriers, and poorer performance in attention in APOEɛ4 allele carriers. There were no associations between carbohydrate intake and cerebral Aβ load. These results provide support to the idea that decreasing carbohydrate intake may offer neurocognitive benefits, with specific cognitive domains affected in an APOE genotype-dependent manner. These findings warrant further investigation utilizing a longitudinal study design.
DOI: 10.3233/JAD-161158
ORCID: 0000-0003-3910-2453
PubMed URL: 28387666
Type: Journal Article
Subjects: Amyloid load
apolipoprotein E
verbal memory
Appears in Collections:Journal articles

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