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Title: The ketogenic diet is effective for refractory epilepsy associated with acquired structural epileptic encephalopathy.
Austin Authors: Villaluz, Mel Michel;Lomax, Lysa Boissé;Jadhav, Trupti;Cross, J Helen;Scheffer, Ingrid E 
Affiliation: Epilepsy Research Centre, Department of Medicine, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australia
Neurosciences Unit, Great Ormond Street Hospital, UCL Institute of Child Health, London, UK
Young Epilepsy, London, UK
Department of Paediatrics, Royal Children's Hospital, The University of Melbourne, Melbourne, Victoria, Australia
Florey Institute of Neuroscience and Mental Health, Melbourne, Victoria, Australia
Issue Date: 16-Feb-2018 2018-02-16
Publication information: Developmental medicine and child neurology 2018; 60(7): 718-723
Abstract: Ketogenic diet therapies have proven efficacy for refractory epilepsy. There are many reports of their use in the genetic developmental and epileptic encephalopathies; however, little attention has been paid as to whether the diet is also effective in individuals with an acquired structural aetiology. We observed remarkable efficacy of the diet in two patients with hypoxic-ischaemic encephalopathy. We then analysed our cases with refractory structural epilepsies of acquired origin to characterize their response to the ketogenic diet. The classical ketogenic diet was implemented with dietary ratios of 3:1 to 4.4:1. Seizure frequency at 1 month, 3 months, 6 months, 1 year, and 2 years was ascertained. A responder was defined as greater than 50% seizure reduction compared to baseline. Seven of the nine patients were responders at 3 months. Somewhat surprisingly we found that the ketogenic diet was effective in patients with a developmental and epileptic encephalopathy due to an acquired structural aetiology. This cohort may not be routinely considered for the ketogenic diet because of their structural and acquired, rather than genetic, basis. The ketogenic diet should be considered early in the management of patients with acquired structural encephalopathies as it can improve seizure control with the potential to improve developmental outcome. The ketogenic diet was effective in children with epilepsy associated with an acquired structural aetiology.
DOI: 10.1111/dmcn.13687
ORCID: 0000-0002-2311-2174
Journal: Developmental medicine and child neurology
PubMed URL: 29451698
Type: Journal Article
Subjects: Brain Injuries/complications
Diet, Ketogenic/methods
Drug Resistant Epilepsy
Appears in Collections:Journal articles

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