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Title: Neuropsychology and neuroimaging profiles of amyloid-positive versus amyloid-negative amnestic mild cognitive impairment patients.
Austin Authors: Tomadesso, Clémence;de La Sayette, Vincent;de Flores, Robin;Bourgeat, Pierrick;Villemagne, Victor L ;Egret, Stéphanie;Eustache, Francis;Chételat, Gaël
Affiliation: Inserm, Inserm U1077, Université de Caen Normandie, Ecole Pratique des Hautes Etudes, Caen, France
Inserm, Inserm UMR-S U1237, Université de Caen-Normandie, GIP Cyceron, Boulevard H. Becquerel, Caen, France
CHU de Caen, Service de Neurologie, Caen, France
CSIRO Digital Productivity Flagship, The Australian e-Health Research Centre-BioMedIA, Herston, Queensland, Australia
Department of Molecular Imaging and Therapy, Centre for PET, Austin Health, Heidelberg, Victoria, Australia
The Florey Institute for Neuroscience and Mental Health, The University of Melbourne, Victoria, Australia
Issue Date: 17-May-2018
Date: 2018-05-17
Publication information: Alzheimer's & dementia (Amsterdam, Netherlands) 2018; 10: 269-277
Abstract: Patients with amnestic mild cognitive impairment (aMCI) are heterogeneous as regard to their amyloid status. The present study aimed at highlighting the neuropsychological, brain atrophy, and hypometabolism profiles of amyloid-positive (Aβpos) versus amyloid-negative (Aβneg) aMCI patients. Forty-four aMCI patients and 24 Aβneg healthy controls underwent neuropsychological, structural magnetic resonance imaging and 18F-fluorodeoxyglucose positron emission tomography scans. Data were compared between groups in specific regions of interest and voxelwise with statistical parametric mapping. When directly comparing Aβpos to Aβneg aMCI, the former had lower performances in episodic memory tests (P = .02 to P < .001) while the latter had worse scores in working memory (P = .01) and language (P < .005). Compared to Aβneg healthy controls, both aMCI subgroups showed similar profiles of atrophy and hypometabolism, with no difference between both aMCI subgroups. In a sample of aMCI patients recruited and scanned in the same center, the main difference at baseline between Aβpos and Aβneg aMCI concerned the neuropsychological profile, but not the structural magnetic resonance imaging or 18F-fluorodeoxyglucose positron emission tomography profiles of brain alterations.
DOI: 10.1016/j.dadm.2018.02.008
Journal: Alzheimer's & dementia (Amsterdam, Netherlands)
PubMed URL: 29780872
ISSN: 2352-8729
Type: Journal Article
Subjects: Alzheimer's disease
Amnestic mild cognitive impairment
Amyloid status
Glucose metabolism
Gray matter volume
Appears in Collections:Journal articles

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