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Title: Total and beverage-specific alcohol intake and the risk of aggressive prostate cancer: a case-control study.
Austin Authors: Papa, Nathan P;MacInnis, R J;Jayasekara, H;English, D R;Bolton, Damien M ;Davis, I D;Lawrentschuk, Nathan;Millar, J L;Pedersen, J;Severi, G;Southey, M C;Hopper, J L;Giles, G G
Affiliation: Monash University Eastern Health Clinical School, Box Hill, Victoria, Australia
Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria, Australia
Eastern Health, Box Hill, Victoria, Australia
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia
Department of Urology, Austin Health, Heidelberg, Victoria, Australia
Olivia Newton-John Cancer Research Institute, Heidelberg, Victoria, Australia
Department of Surgical Oncology, Peter MacCallum Cancer Institute, Melbourne, Victoria, Australia
Alfred Health Radiation Oncology, The Alfred Hospital, Prahran, Victoria, Australia
TissuPath, Melbourne, Victoria, Australia
Genetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, Melbourne, Victoria, Australia
Issue Date: Sep-2017
Date: 2017-08-18
Publication information: Prostate cancer and prostatic diseases 2017; 20(3): 305-310
Abstract: Ethanol in alcoholic beverages is a known carcinogen, but its association with aggressive prostate cancer (APC) is uncertain. Recent studies have shown a modest increase in risk of APC associated with heavy alcohol intake while association for beverage types remain inconsistent. Using a case-control design and self-administered questionnaire, we examined the association between APC (high grade and/or advanced stage) and frequency and quantity of alcohol intake 2 years prior to enrolment. Furthermore, we delineated the relationships for beverage-specific intakes of beer, red wine, white wine and spirits. The study included 1282 APC cases and 951 controls. Beer intake frequency of ⩾5 days per week was associated with increased risk compared with no beer intake (odds ratio=1.66, 95% confidence interval: 1.12-2.48) whereas wine was protective at all frequencies of consumption compared with those with no wine intake. For every 10 g per week ethanol intake from beer increase, the odds of advanced PC rose by 3% (OR=1.03, 95% CI: 1.02-1.05). No such increased risk was observed for red or white wine while a marginal dose-response relationship was found for spirits (OR=1.03, 95% CI: 0.99-1.07). Heavy beer and possibly spirits consumption is associated with increased risk while no dose-response relationship was found for red or white wine. Wine drinkers at all frequencies have a decreased risk of APC compared with those who did not drink wine.
DOI: 10.1038/pcan.2017.12
ORCID: 0000-0002-2453-0183
Journal: Prostate cancer and prostatic diseases
PubMed URL: 28417982
Type: Journal Article
Appears in Collections:Journal articles

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