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Title: Haemoglobin concentration and volume of intravenous fluids in septic shock in the ARISE trial.
Austin Authors: Maiden, Matthew J;Finnis, Mark E;Peake, Sandra;McRae, Simon;Delaney, Anthony;Bailey, Michael;Bellomo, Rinaldo 
Affiliation: Intensive Care Unit, University Hospital Geelong, Barwon Health, Geelong, Victoria, Australia
Intensive Care Unit, Royal Adelaide Hospital, Adelaide, South Australia, Australia
Discipline of Acute Care Medicine, University of Adelaide, Adelaide, Australia
Department of Intensive Care Medicine, The Queen Elizabeth Hospital, Adelaide, South Australia, Australia
Australian and New Zealand Intensive Care Research Centre, Monash University, Clayton, Victoria, Australia
Department of Haematology, SA Pathology, Adelaide, South Australia, Australia
Intensive Care Unit, Royal North Shore Hospital, St Leonard's, New South Wales, Australia
Northern Clinical School, Sydney Medical School, University of Sydney, Clayton, Australia
Critical Care Services, Monash Health, Clayton, Victoria, Australia
School of Medicine, University of Melbourne, Melbourne, Victoria, Australia
Intensive Care Unit, Austin Health, Heidelberg, Victoria, Australia
Department of Intensive Care, Royal Melbourne Hospital, Melbourne, Australia
Issue Date: 3-May-2018 2018-05-03
Publication information: Critical Care 2018; 22(1): 118
Abstract: Intravenous fluids may contribute to lower haemoglobin levels in patients with septic shock. We sought to determine the relationship between the changes in haemoglobin concentration and the volume of intravenous fluids administered during resuscitation from septic shock. We performed a retrospective cohort study of patients enrolled in the Australasian Resuscitation in Sepsis Evaluation (ARISE) trial who were not transfused red blood cells (N = 1275). We determined the relationship between haemoglobin concentration, its change over time and volume of intravenous fluids administered over 6, 24 and 72 h using univariate and multivariate analysis. Median (IQR) haemoglobin concentration at baseline was 133 (118-146) g/L and decreased to 115 (102-127) g/L within the first 6 h of resuscitation (P < 0.001), 110 (99-122) g/L after 24 h, and 109 (97-121) g/L after 72 h. At the corresponding time points, the cumulative volume of intravenous fluid administered was 1.3 (0.7-2.2) L, 2.9 (1.8-4.3) L and 4.6 (2.7-7.1) L. Haemoglobin concentration and its change from baseline had an independent but weak association with intravenous fluid volume at each time point (R2 < 20%, P < 0.001). After adjusting for covariates, each litre of intravenous fluid administered was associated with a change in haemoglobin concentration of - 1.0 g/L (95% CI -1.5 to -0.6, P < 0.001) at 24 h and - 1.3 g/L (- 1.6 to - 0.9, P < 0.001) at 72 h. Haemoglobin concentration decreases during resuscitation from septic shock, and has a significant but weak association with the volume of intravenous fluids administered.
DOI: 10.1186/s13054-018-2029-6
ORCID: 0000-0002-1650-8939
PubMed URL: 29724246
Type: Journal Article
Subjects: Fluids
Septic shock
Appears in Collections:Journal articles

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