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Title: Subthalamic nucleus deep brain stimulation evokes resonant neural activity.
Austin Authors: Sinclair, Nicholas C;McDermott, Hugh J;Bulluss, Kristian J ;Fallon, James B;Perera, Thushara;Xu, San San ;Brown, Peter;Thevathasan, Wesley
Affiliation: Bionics Institute, East Melbourne, Victoria, Australia
Department of Medical Bionics, University of Melbourne, East Melbourne, Victoria, Australia
Department of Neurosurgery, St Vincent's Hospital Melbourne, Fitzroy, Victoria, Australia
Department of Neurosurgery, Austin Health, Heidelberg, Victoria, Australia
Department of Neurology, Austin Health, Heidelberg, Victoria, Australia
Medical Research Council Brain Network Dynamics Unit and Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom
Department of Medicine, University of Melbourne, Parkville, Australia
Department of Neurology, Royal Melbourne Hospital, Parkville, Australia
Issue Date: 2018
Date: 2018-05-04
Publication information: Annals of neurology 2018; 83(5): 1027-1031
Abstract: Deep brain stimulation (DBS) is a rapidly expanding treatment for neurological and psychiatric conditions; however, a target-specific biomarker is required to optimize therapy. Here, we show that DBS evokes a large-amplitude resonant neural response focally in the subthalamic nucleus. This response is greatest in the dorsal region (the clinically optimal stimulation target for Parkinson disease), coincides with improved clinical performance, is chronically recordable, and is present under general anesthesia. These features make it a readily utilizable electrophysiological signal that could potentially be used for guiding electrode implantation surgery and tailoring DBS therapy to improve patient outcomes. Ann Neurol 2018.
DOI: 10.1002/ana.25234
Journal: Annals of neurology
PubMed URL: 29727475
Type: Journal Article
Appears in Collections:Journal articles

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